Zinc acutely and temporarily inhibits adrenal cortisol secretion in humans. A preliminary report

[Gianluca]

Abstract​

Hypo- and hyperzincemia has been reported to cause alterations in the adrenal secretion. To determine the acute effect of zinc on cortisol levels, we studied 27 normal individuals of both sexes aged 20-27 y after a 12-h fast. The tests were initiated at 7:00 AM when an antecubital vein was punctured and a device for infusion was installed and maintained with physiological saline. Zinc was administered orally at 8:00 AM. Subjects were divided into an experimental group of 13 individuals who received doses of 25, 37.5, and 50 mg of zinc and a control group of 14 individual who received 20 mL of physiological saline. Serial blood samples were collected over a period of 240 min after basal samples (-30 and 0 min). We detected an acute inhibitory effect of zinc on cortisol secretion during 240 min of the study period in the experimental group.

Zinc acutely and temporarily inhibits adrenal cortisol secretion in humans. A preliminary report - PubMed

Hypo- and hyperzincemia has been reported to cause alterations in the adrenal secretion. To determine the acute effect of zinc on cortisol levels, we studied 27 normal individuals of both sexes aged 20-27 y after a 12-h fast. The tests were initiated at 7:00 AM when an antecubital vein was...

pubmed.ncbi.nlm.nih.gov

 

[Nelson Vergel]

Thank you. Good to know. I don’t want to inhibit my cortisol ! Get aches when I do. And it’s hard to wake up in the morning.

 

[Gladiator]

I have been taking 25mg of zinc for 3 years.

 

[Sergel]

So one should supplement with zinc at night?

 

[Gianluca]

So one should supplement with zinc at night?

If you have higher than normal cortisol at night it would be a good idea, otherwise in my opinion, zinc like most nutrients, are good to take mostly from food. Read meat is a good source of zinc