Why less frequent injection intervalls with high SHBG?

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krm

Member
Hi all, it seems common that with high SHGB, less frequent injection intervals - once per week - are recommended.

I couldn't find anything on the reasoning behind this; why does a higher dose of injected test apparently lower shgb levels to a certain extent, and why wouldn't a "steady state" (frequent injections) be equally effective for higher shbg levels?

It seems somewhat counterintuitive...

Thanks!
 
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krm

Member
I understand this line of thinking, what I meant is I don't understand the underlying logic - why would a peak of testosterone influence the level of the hormone that is binding the testosterone?
 

Systemlord

Member
Testosterone, androgens affects the livers output of SHBG, the liver must metabolize testosterone and that creates a load on the liver.

Sometimes in some men SHBG will increase after starting TRT which is do to insulin resistance negatively affecting the livers output of SHBG. Insulin resistance will lower SHBG.
 
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