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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Who Started TRT w/ "Normal" Levels @ What Age?
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<blockquote data-quote="Cataceous" data-source="post: 214165" data-attributes="member: 38109"><p>At least in the clinical trials enclomiphene modestly increased estradiol. But it's true that the blocking of certain estrogen receptors may do both good and bad things, depending on the individual and the dose. The criticism of enclomiphene is that you can have great looking numbers but poor subjective results. Given this unpredictability I do recommend the nasal gel as a first choice.</p><p></p><p>On the subject of risk I do have bias, both from personal experience and from contact with forum members struggling with TRT-related issues. The latter most likely are overrepresented compared to the general TRT population. But I've also learned a little about the complex interplay of hormones involved in the HPTA and beyond, and have come to appreciate that we don't even know all of the possible long-term consequences of disrupting things. Regarding more specific items, TRT can cause testicular atrophy and loss of fertility. Paradoxically, even libido can be worse. It's common to use hCG to prevent these issues, but hCG frequently raises estradiol unnaturally, and secondarily prolactin can rise and cause problems. If TRT isn't properly managed then estradiol can be too high even without hCG. Elevated hematocrit is also a common problem.</p><p></p><p>Given all this I think it makes sense to start with a less invasive approach, and the nasal gel fits the bill.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 214165, member: 38109"] At least in the clinical trials enclomiphene modestly increased estradiol. But it's true that the blocking of certain estrogen receptors may do both good and bad things, depending on the individual and the dose. The criticism of enclomiphene is that you can have great looking numbers but poor subjective results. Given this unpredictability I do recommend the nasal gel as a first choice. On the subject of risk I do have bias, both from personal experience and from contact with forum members struggling with TRT-related issues. The latter most likely are overrepresented compared to the general TRT population. But I've also learned a little about the complex interplay of hormones involved in the HPTA and beyond, and have come to appreciate that we don't even know all of the possible long-term consequences of disrupting things. Regarding more specific items, TRT can cause testicular atrophy and loss of fertility. Paradoxically, even libido can be worse. It's common to use hCG to prevent these issues, but hCG frequently raises estradiol unnaturally, and secondarily prolactin can rise and cause problems. If TRT isn't properly managed then estradiol can be too high even without hCG. Elevated hematocrit is also a common problem. Given all this I think it makes sense to start with a less invasive approach, and the nasal gel fits the bill. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Who Started TRT w/ "Normal" Levels @ What Age?
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