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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
TRT to Supraphysiological Levels for Body Building
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<blockquote data-quote="tareload" data-source="post: 218037"><p>Thanks for taking a look and providing your feedback. Regarding your point above, I see where I may have misled people in post #93. In that post I <strong>extrapolated</strong> the logarithmic regression line for the rodent data back to TRT-type doses and observed the model implied a toxic effect within 10 years:</p><p></p><p>EDIT: if you are curious what the regression line (above) <u><strong>predicts</strong></u> for various HEDs:</p><table class='post-table ' style='width: 100%'><tr><td ><p>HED (mg/week for 90 kg man)</p></td><td ><p>duration (human years)</p></td></tr><tr><td ><p>25</p></td><td ><p>8.6 (extrapolation)</p></td></tr><tr><td ><p>50</p></td><td ><p>7.4 (extrapolation)</p></td></tr><tr><td ><p>100</p></td><td ><p>6.2 (extrapolation)</p></td></tr><tr><td ><p>200</p></td><td ><p>5.0</p></td></tr><tr><td ><p>400</p></td><td ><p>3.9</p></td></tr><tr><td ><p>800</p></td><td ><p>2.7</p></td></tr><tr><td ><p>1600</p></td><td ><p>1.5</p></td></tr><tr><td ><p>3200</p></td><td ><p>0.3</p></td></tr></table>Extrapolating is a big leap. Afterwards I added two data points to adjust the best fit curve to reflect doses under 100 mg/week were non-toxic for practical purposes (again one has to understand the serum levels at the individual level for each dosage/dosing strategy). Hence the real question is if there are "TRT" dose data for rodents and where they would show up on the curve.</p><p></p><p></p><p></p><p>I've found some Test Ester PK data for rodents and I'll review that at some point in this thread in the context of their typical baseline serum levels.</p></blockquote><p></p>
[QUOTE="tareload, post: 218037"] Thanks for taking a look and providing your feedback. Regarding your point above, I see where I may have misled people in post #93. In that post I [B]extrapolated[/B] the logarithmic regression line for the rodent data back to TRT-type doses and observed the model implied a toxic effect within 10 years: EDIT: if you are curious what the regression line (above) [U][B]predicts[/B][/U] for various HEDs: [TABLE][TR][TD] HED (mg/week for 90 kg man) [/TD] [TD] duration (human years) [/TD][/TR] [TR][TD] 25 [/TD] [TD] 8.6 (extrapolation) [/TD][/TR] [TR][TD] 50 [/TD] [TD] 7.4 (extrapolation) [/TD][/TR] [TR][TD] 100 [/TD] [TD] 6.2 (extrapolation) [/TD][/TR] [TR][TD] 200 [/TD] [TD] 5.0 [/TD][/TR] [TR][TD] 400 [/TD] [TD] 3.9 [/TD][/TR] [TR][TD] 800 [/TD] [TD] 2.7 [/TD][/TR] [TR][TD] 1600 [/TD] [TD] 1.5 [/TD][/TR] [TR][TD] 3200 [/TD] [TD] 0.3 [/TD][/TR][/TABLE] Extrapolating is a big leap. Afterwards I added two data points to adjust the best fit curve to reflect doses under 100 mg/week were non-toxic for practical purposes (again one has to understand the serum levels at the individual level for each dosage/dosing strategy). Hence the real question is if there are "TRT" dose data for rodents and where they would show up on the curve. I've found some Test Ester PK data for rodents and I'll review that at some point in this thread in the context of their typical baseline serum levels. [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
TRT to Supraphysiological Levels for Body Building
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