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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT Accelerates Artery Plaque Buildup
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<blockquote data-quote="madman" data-source="post: 211840" data-attributes="member: 13851"><p><strong>Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone (2017)</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Design, Settings, and Participants</strong></p><p></p><p><em><strong>A double-blinded, placebo-controlled trial at </strong></em><strong><em><strong>9 a</strong>cademic medical centers in the United States. </em></strong><em>The participants were 170 of 788 men aged 65 years or older with an average of 2 serum testosterone levels lower than 275 ng/dL (82 men assigned to placebo, 88 to testosterone) and symptoms suggestive of hypogonadism who were <strong>enrolled in the <u>Testosterone Trials</u> between June 24, 2010, and June 9, 2014.</strong></em></p><p></p><p></p><p><strong>Conclusions and Relevance</strong></p><p></p><p><em>Among older men with symptomatic hypogonadism, treatment with testosterone gel for 1 year compared with placebo was <strong>associated with a significantly greater increase in coronary artery noncalcified plaque volume, as measured by coronary computed tomographic angiography. <u>Larger studies are needed to understand the clinical implications of this finding</u>.</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<u>T Trials</u> found a statistically significant 1-year increase in noncalcified plaque volume (estimated difference 41 mm3 [95% CI 14 to 67 mm3 ]) in hypogonadal elderly males receiving testosterone therapy compared to the placebo group. 29 <u>no statistically significant difference was found in the number of cardiovascular events or calcified plaque progression between the intervention and control group</u>.29</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 211840, member: 13851"] [B]Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone (2017) Design, Settings, and Participants[/B] [I][B]A double-blinded, placebo-controlled trial at [/B][/I][B][I][B]9 a[/B]cademic medical centers in the United States. [/I][/B][I]The participants were 170 of 788 men aged 65 years or older with an average of 2 serum testosterone levels lower than 275 ng/dL (82 men assigned to placebo, 88 to testosterone) and symptoms suggestive of hypogonadism who were [B]enrolled in the [U]Testosterone Trials[/U] between June 24, 2010, and June 9, 2014.[/B][/I] [B]Conclusions and Relevance[/B] [I]Among older men with symptomatic hypogonadism, treatment with testosterone gel for 1 year compared with placebo was [B]associated with a significantly greater increase in coronary artery noncalcified plaque volume, as measured by coronary computed tomographic angiography. [U]Larger studies are needed to understand the clinical implications of this finding[/U]. *[U]T Trials[/U] found a statistically significant 1-year increase in noncalcified plaque volume (estimated difference 41 mm3 [95% CI 14 to 67 mm3 ]) in hypogonadal elderly males receiving testosterone therapy compared to the placebo group. 29 [U]no statistically significant difference was found in the number of cardiovascular events or calcified plaque progression between the intervention and control group[/U].29[/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT Accelerates Artery Plaque Buildup
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