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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Thoughts on my most recent bloodwork? IS my E2 too high?
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<blockquote data-quote="madman" data-source="post: 203222" data-attributes="member: 13851"><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/am-i-eligible-to-trt-considering-the-following.23550/[/URL]</p><p></p><p>Hello everyone,</p><p></p><p><em><strong>First off, the number bits:</strong></em></p><p><em><strong>- TT: 480 (240-870)</strong></em></p><p><em><strong>- FT: 10 (8-40)</strong></em></p><p><em><strong>- e2: 15 (11-44)</strong></em></p><p><em><strong></strong></em></p><p><em><strong>After 2 months taking a B-vitamin complex:</strong></em></p><p><em><strong>- TT: 860 (240-870)</strong></em></p><p><em><strong>- FT: 11 (8-40)</strong></em></p><p><strong><em>- e2: 15 (11-44)</em></strong></p><p></p><p></p><p>Hard to believe you achieved a significant bump in T from the simple addition of b-vitamins!</p><p></p><p>Unfortunately, you have no idea where your SHBG sits let alone FT as you never had it tested using an accurate assay.</p><p></p><p>I would not rely on the piss poor direct immunoassay let alone outdated calculated methods especially in cases of altered SHBG</p><p></p><p>Although the newer cFTZ algorithm (TruT) should give fairly consistent results I would prefer to rely on direct testing using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration especially in cases of <u>altered SHBG</u>.</p><p></p><p>The EAM (cFTZ) appears to be an accurate and testable model for calculating free testosterone levels, but this model needs further validation in large populations.</p><p></p><p>This will be a part of the ongoing phase II.</p><p></p><p>As I am patiently waiting on the completion of Phase II for the TruT (cFTZ) Algorithm let alone standardization and harmonized reference ranges for Free testosterone which is in the works as we speak.</p><p></p><p></p><p><strong>The new dynamic model leads to the reconsideration of several dogmas related to testosterone's binding to SHBG and has important physiologic and clinical implications.</strong></p><p><strong></strong></p><p><strong><em>*First, the fraction of circulating testosterone that is free is substantially greater (2.9±0.4%)</em></strong><em> <strong>than has been generally assumed (% cFTV 1.5±0.4%)</strong>.</em></p><p><em></em></p><p><em><strong>*Second, percent FT is not significantly related to total testosterone over a wide range of total testosterone concentrations. However, the percent FT declines as SHBG concentrations increase, although it does not decline as precipitously as predicted by Vermeulen's model. Due to the allostery between the two binding sites, <u>SHBG is able to regulate FT levels in a much larger dynamic range</u>.</strong></em></p><p></p><p></p><p>Key points:</p><p></p><p><strong>EAM (cFTZ) SHBG: T binding</strong></p><p><strong></strong></p><p><strong><em>*</em></strong><em><strong>Intra-dimer complex allostery suggests that<u> SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated</u>.</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Indeed, it was found that percent FT calculated using the new model <u>changed very modestly over a wide range of total testosterone concentrations</u>.</strong></em></p><p></p><p><strong><em>*Due to the allostery between the two binding sites, <u>SHBG is able to regulate FT levels in a much larger dynamic range</u>.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 203222, member: 13851"] [URL unfurl="true"]https://www.excelmale.com/forum/threads/am-i-eligible-to-trt-considering-the-following.23550/[/URL] Hello everyone, [I][B]First off, the number bits: - TT: 480 (240-870) - FT: 10 (8-40) - e2: 15 (11-44) After 2 months taking a B-vitamin complex: - TT: 860 (240-870) - FT: 11 (8-40)[/B][/I] [B][I]- e2: 15 (11-44)[/I][/B] Hard to believe you achieved a significant bump in T from the simple addition of b-vitamins! Unfortunately, you have no idea where your SHBG sits let alone FT as you never had it tested using an accurate assay. I would not rely on the piss poor direct immunoassay let alone outdated calculated methods especially in cases of altered SHBG Although the newer cFTZ algorithm (TruT) should give fairly consistent results I would prefer to rely on direct testing using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration especially in cases of [U]altered SHBG[/U]. The EAM (cFTZ) appears to be an accurate and testable model for calculating free testosterone levels, but this model needs further validation in large populations. This will be a part of the ongoing phase II. As I am patiently waiting on the completion of Phase II for the TruT (cFTZ) Algorithm let alone standardization and harmonized reference ranges for Free testosterone which is in the works as we speak. [B]The new dynamic model leads to the reconsideration of several dogmas related to testosterone's binding to SHBG and has important physiologic and clinical implications. [I]*First, the fraction of circulating testosterone that is free is substantially greater (2.9±0.4%)[/I][/B][I] [B]than has been generally assumed (% cFTV 1.5±0.4%)[/B]. [B]*Second, percent FT is not significantly related to total testosterone over a wide range of total testosterone concentrations. However, the percent FT declines as SHBG concentrations increase, although it does not decline as precipitously as predicted by Vermeulen's model. Due to the allostery between the two binding sites, [U]SHBG is able to regulate FT levels in a much larger dynamic range[/U].[/B][/I] Key points: [B]EAM (cFTZ) SHBG: T binding [I]*[/I][/B][I][B]Intra-dimer complex allostery suggests that[U] SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated[/U]. *Indeed, it was found that percent FT calculated using the new model [U]changed very modestly over a wide range of total testosterone concentrations[/U].[/B][/I] [B][I]*Due to the allostery between the two binding sites, [U]SHBG is able to regulate FT levels in a much larger dynamic range[/U].[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Thoughts on my most recent bloodwork? IS my E2 too high?
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