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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Thoughts on my most recent bloodwork? IS my E2 too high?
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<blockquote data-quote="madman" data-source="post: 203215" data-attributes="member: 13851"><p>As of now, there is no gold standard for measuring SHBG.</p><p></p><p>The most common methodology used is Electrochemiluminescence immunoassay (ECLIA).</p><p></p><p>Depending on the lab different immunoassay platforms are used such as Abbott Architect, Roche, Beckman, and Siemens</p><p></p><p>Keep in mind that there can be significant differences in SHBG results produced by different analyzers.</p><p></p><p></p><p><strong><em>*The effects of using different testosterone assays on the estimated CFT have been studied in detail, and <u>reference measurement procedures and standard reference materials are available for testosterone to enable traceability of routine laboratory methods to higher-order reference methods and materials</u>. This has had some success in standardizing testosterone measurement across laboratories, although not all manufacturers of commercial assays have been involved and further improvement is still required.</em></strong><em><strong> <u>However, only limited attempts have been made to standardize other components of the CFT equations, </u></strong></em><strong><em><u>such as SHBG</u>.</em></strong></p><p></p><p></p><p></p><p>When it comes to free testosterone the most accurate assays would be the gold standard Equilibrium Dialysis or Ultrafiltration (next best).</p><p></p><p>As of now, there is no standardization let alone harmonized reference range for FT which is in the works as we speak.</p><p></p><p>The same can be said for SHBG.</p><p></p><p></p><p></p><p></p><p></p><p><strong>post #2</strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/cdcs-clinical-standardization-programs-free-testosterone-soon-to-be.23242/[/URL]</p><p></p><p><strong>10:50-16:10</strong></p><p><strong></strong></p><p><strong>(11:46-12:00)<em> As part of our testosterone work, we are interested in SHBG. We are working very hard right now on a free testosterone method (reference method) and are making good progress on that one.</em></strong></p><p><strong><em>[ATTACH=full]15092[/ATTACH]</em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em>Standardization and harmonized programs in development</em></strong><em><strong> PTH, Thyroid function tests (Free and total T4 and TSH),</strong></em> <strong><em><u>Free testosterone, Binding proteins</u></em></strong></p><p>[ATTACH=full]15089[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 203215, member: 13851"] As of now, there is no gold standard for measuring SHBG. The most common methodology used is Electrochemiluminescence immunoassay (ECLIA). Depending on the lab different immunoassay platforms are used such as Abbott Architect, Roche, Beckman, and Siemens Keep in mind that there can be significant differences in SHBG results produced by different analyzers. [B][I]*The effects of using different testosterone assays on the estimated CFT have been studied in detail, and [U]reference measurement procedures and standard reference materials are available for testosterone to enable traceability of routine laboratory methods to higher-order reference methods and materials[/U]. This has had some success in standardizing testosterone measurement across laboratories, although not all manufacturers of commercial assays have been involved and further improvement is still required.[/I][/B][I][B] [U]However, only limited attempts have been made to standardize other components of the CFT equations, [/U][/B][/I][B][I][U]such as SHBG[/U].[/I][/B] When it comes to free testosterone the most accurate assays would be the gold standard Equilibrium Dialysis or Ultrafiltration (next best). As of now, there is no standardization let alone harmonized reference range for FT which is in the works as we speak. The same can be said for SHBG. [B]post #2[/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/cdcs-clinical-standardization-programs-free-testosterone-soon-to-be.23242/[/URL] [B]10:50-16:10 (11:46-12:00)[I] As part of our testosterone work, we are interested in SHBG. We are working very hard right now on a free testosterone method (reference method) and are making good progress on that one. [ATTACH type="full" alt="Screenshot (5535).png"]15092[/ATTACH] Standardization and harmonized programs in development[/I][/B][I][B] PTH, Thyroid function tests (Free and total T4 and TSH),[/B][/I] [B][I][U]Free testosterone, Binding proteins[/U][/I][/B] [ATTACH type="full" alt="1624513043693.png"]15089[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Thoughts on my most recent bloodwork? IS my E2 too high?
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