ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
General Health & Fitness
Health & Wellness
Thoughts on David Sinclair research
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="FunkOdyssey" data-source="post: 230097" data-attributes="member: 44064"><p>Grip strength, gait speed, chair stand test -- these basic physical function tests are the biomarkers that rule them all. They predict everything from depression, cognition, surgery recovery, CHD risk, cancer risk, dementia risk, and most importantly all-cause mortality. Here's a good free text review: <a href="https://pubmed.ncbi.nlm.nih.gov/31631989/" target="_blank">Grip Strength: An Indispensable Biomarker For Older Adults - PubMed</a></p><p></p><p>Here's a typical study associating grip strength with all-cause mortality:</p><p>[URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/35639798/[/URL]</p><p></p><p>[ATTACH=full]24562[/ATTACH]</p><p></p><p>The literature on this is overwhelming to the point that I don't even know where to start to present some interesting findings. I searched "gait speed mortality" on pubmed and it returned over 900 results: <a href="https://pubmed.ncbi.nlm.nih.gov/?term=gait+speed+mortality&sort=date" target="_blank">gait speed mortality - Search Results - PubMed</a></p><p></p><p>So this is where I think the research anti-aging scientists are doing in lower life forms may not directly translate to human longevity. If you restrict calories and protein and avoid anything anabolic you might reduce your cellular rate of aging and then become so frail, sarcopenic and osteoporotic that you die anyway from a simple fall.</p><p></p><p></p><p></p><p>I would like to pursue the hybrid approach and I don't see why you wouldn't. Look at Peter Attia, he talks often about how he is training for the "centenarian olympics" and is very concerned with carrying enough muscle mass into old age to maintain his mobility and physical function, while using time-restricted feeding, periodic fasting, and a weekly dose of rapamycin to slow his aging. I suppose professional bodybuilding is incompatible with longevity but there's no reason you can't be both athletic and long-lived.</p><p></p><p>Testosterone probably has a mixture of dose-dependent positive and negative effects on longevity, and the net effect doesn't seem obvious to me. Contrast with growth hormone: GH and IGF-1 are without question having a strong negative impact on lifespan at increasing levels. That's definitely one to avoid if you are concerned.</p></blockquote><p></p>
[QUOTE="FunkOdyssey, post: 230097, member: 44064"] Grip strength, gait speed, chair stand test -- these basic physical function tests are the biomarkers that rule them all. They predict everything from depression, cognition, surgery recovery, CHD risk, cancer risk, dementia risk, and most importantly all-cause mortality. Here's a good free text review: [URL="https://pubmed.ncbi.nlm.nih.gov/31631989/"]Grip Strength: An Indispensable Biomarker For Older Adults - PubMed[/URL] Here's a typical study associating grip strength with all-cause mortality: [URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/35639798/[/URL] [ATTACH type="full"]24562[/ATTACH] The literature on this is overwhelming to the point that I don't even know where to start to present some interesting findings. I searched "gait speed mortality" on pubmed and it returned over 900 results: [URL="https://pubmed.ncbi.nlm.nih.gov/?term=gait+speed+mortality&sort=date"]gait speed mortality - Search Results - PubMed[/URL] So this is where I think the research anti-aging scientists are doing in lower life forms may not directly translate to human longevity. If you restrict calories and protein and avoid anything anabolic you might reduce your cellular rate of aging and then become so frail, sarcopenic and osteoporotic that you die anyway from a simple fall. I would like to pursue the hybrid approach and I don't see why you wouldn't. Look at Peter Attia, he talks often about how he is training for the "centenarian olympics" and is very concerned with carrying enough muscle mass into old age to maintain his mobility and physical function, while using time-restricted feeding, periodic fasting, and a weekly dose of rapamycin to slow his aging. I suppose professional bodybuilding is incompatible with longevity but there's no reason you can't be both athletic and long-lived. Testosterone probably has a mixture of dose-dependent positive and negative effects on longevity, and the net effect doesn't seem obvious to me. Contrast with growth hormone: GH and IGF-1 are without question having a strong negative impact on lifespan at increasing levels. That's definitely one to avoid if you are concerned. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
General Health & Fitness
Health & Wellness
Thoughts on David Sinclair research
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top