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Thoughts on David Sinclair research
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<blockquote data-quote="FunkOdyssey" data-source="post: 229998" data-attributes="member: 44064"><p>I was a moderator of a longevity forum for many years, called the Immortality Institute in the early days and now Longecity.org. That gave me a front row seat to the rise and fall of resveratrol and Sinclair's fall from grace along with it. Somehow, he has managed to rebrand himself as the public face of anti-aging science after writing a very popular book, Lifespan: Why We Age and Why We Don't Have To.</p><p></p><p>The most exciting compounds available right now are rapamycin and senolytics, including fisetin, dasatinib, and quercetin. These may actually slow or reverse signs of aging. Rapamycin consistently extends lifespan in animal studies even when started in mid or late life. I've been trying to get my father to start on it with Dr. Alan Green who prescribes it via telemedicine.</p><p></p><p>Peter Attia doesn't have a book but he is a better source of information in my opinion if the topic interests you.</p><p></p><p>[URL unfurl="true"]https://peterattiamd.com/[/URL]</p><p></p><p>Back to Sinclair, listen to him talk for five minutes about TRT and why he thinks it will shorten our lifespans in this podcast:</p><p>[MEDIA=youtube]RUiRFGX1Oqs:328[/MEDIA]</p><p></p><p>The basis for his opinion is purely theoretical: factors that suppress growth and reproduction generally extend life (IGF-1 knockout, mTOR inhibition, calorie restriction). Testosterone supports tissue growth and reproduction so it must shorten lifespan. </p><p></p><p>Two of the very best predictors of how much time you have left are your grip strength and walking speed. What effect do you think testosterone will have on those parameters?</p><p></p><p>The only facts cited to support his position are that eunuchs have been observed to live longer than intact males. There is no acknowledgement of other variables that could have influenced their longevity. In my opinion his thinking is sloppy.</p></blockquote><p></p>
[QUOTE="FunkOdyssey, post: 229998, member: 44064"] I was a moderator of a longevity forum for many years, called the Immortality Institute in the early days and now Longecity.org. That gave me a front row seat to the rise and fall of resveratrol and Sinclair's fall from grace along with it. Somehow, he has managed to rebrand himself as the public face of anti-aging science after writing a very popular book, Lifespan: Why We Age and Why We Don't Have To. The most exciting compounds available right now are rapamycin and senolytics, including fisetin, dasatinib, and quercetin. These may actually slow or reverse signs of aging. Rapamycin consistently extends lifespan in animal studies even when started in mid or late life. I've been trying to get my father to start on it with Dr. Alan Green who prescribes it via telemedicine. Peter Attia doesn't have a book but he is a better source of information in my opinion if the topic interests you. [URL unfurl="true"]https://peterattiamd.com/[/URL] Back to Sinclair, listen to him talk for five minutes about TRT and why he thinks it will shorten our lifespans in this podcast: [MEDIA=youtube]RUiRFGX1Oqs:328[/MEDIA] The basis for his opinion is purely theoretical: factors that suppress growth and reproduction generally extend life (IGF-1 knockout, mTOR inhibition, calorie restriction). Testosterone supports tissue growth and reproduction so it must shorten lifespan. Two of the very best predictors of how much time you have left are your grip strength and walking speed. What effect do you think testosterone will have on those parameters? The only facts cited to support his position are that eunuchs have been observed to live longer than intact males. There is no acknowledgement of other variables that could have influenced their longevity. In my opinion his thinking is sloppy. [/QUOTE]
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Thoughts on David Sinclair research
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