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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Thinking of trying metformin with TRT
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<blockquote data-quote="dickielongate" data-source="post: 152273" data-attributes="member: 38930"><p>Even more intrigue, there seems to be a different pathway for metformin interaction with thyroid hormones:</p><p></p><p><a href="http://www.thetrp.net/article.asp?issn=0973-0354;year=2012;volume=9;issue=3;spage=75;epage=77;aulast=Kalra" target="_blank">Metformin and the thyroid: An unexplored therapeutic option Kalra S, Dhamija P, Unnikrishnan AG - Thyroid Res Pract</a></p><p></p><p>If I understand correctly, metformin lowers tsh, but not in isolation. I couldn't derive if lowered TSH was due to feedback from T3/T4 levels, but since the article mentions therapeutic benefit I assume the lowered TSH was not accompanied by lower T4/T3.</p><p></p><p>I am covering lots of ground and will slow down and process it all. My metformin will arrive soon. I am impatient (being honest) and can't see any reason not to try it.</p><p></p><p>Edit: Clarification here that lowered TSH from metformin did not produce changes in T3/T4, therefore the impact seems to be on TSH efficiency I guess?:</p><p></p><p><a href="https://joe.bioscientifica.com/view/journals/joe/233/1/R43.xml" target="_blank">https://joe.bioscientifica.com/view/journals/joe/233/1/R43.xml</a></p></blockquote><p></p>
[QUOTE="dickielongate, post: 152273, member: 38930"] Even more intrigue, there seems to be a different pathway for metformin interaction with thyroid hormones: [URL='http://www.thetrp.net/article.asp?issn=0973-0354;year=2012;volume=9;issue=3;spage=75;epage=77;aulast=Kalra']Metformin and the thyroid: An unexplored therapeutic option Kalra S, Dhamija P, Unnikrishnan AG - Thyroid Res Pract[/URL] If I understand correctly, metformin lowers tsh, but not in isolation. I couldn't derive if lowered TSH was due to feedback from T3/T4 levels, but since the article mentions therapeutic benefit I assume the lowered TSH was not accompanied by lower T4/T3. I am covering lots of ground and will slow down and process it all. My metformin will arrive soon. I am impatient (being honest) and can't see any reason not to try it. Edit: Clarification here that lowered TSH from metformin did not produce changes in T3/T4, therefore the impact seems to be on TSH efficiency I guess?: [URL]https://joe.bioscientifica.com/view/journals/joe/233/1/R43.xml[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Thinking of trying metformin with TRT
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