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General Health & Fitness
Nutrition and Supplements
The HCG Diet: Does It Work?
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<blockquote data-quote="Nelson Vergel" data-source="post: 136226" data-attributes="member: 3"><p><strong>HCG Injections in a Randomized, Double-Blinded, Placebo-Controlled Trial</strong></p><p></p><p></p><p><a href="http://dremma.com/wp-content/uploads/2016/11/SE-Poster-Final.pdf" target="_blank">Source</a></p><p></p><p>Four week trials were conducted on a total of <strong>59 females </strong>between the ages of 20 and 55, with no major medical illness. They were placed on a 500 calorie diet (50% protein). Measured parameters: weight, body composition via bioimpedance, blood pressure, and blood labs were performed. Subjects received daily hCG or saline (placebo) subcutaneous injections. After 4 weeks, the subjects body compositions were analyzed for overall change. There was significantly more muscle lost in the placebo group versus the HCG group. Overall weight loss was similar between the two groups. This lends support to the theory that HCG is acting to preserve lean body mass during a calorie deprived state.</p><p></p><p>59 females were randomized to HCG or Placebo Study Groups. All subjects were between the ages of 20 and 55, with no major medical conditions. Recorded variables: weight, body composition, blood pressure, blood labs (CBC, complete metabolic panel, thyroid panel, hormones, and B-HCG), and in some patients, EKG. All were placed on a 500 calorie diet (approximately 50% protein) and were instructed to keep a diary of progress, hunger, and a food log. Subjects were randomized to HCG or placebo (saline) and injected between 200 and 300 IU subcutaneously daily for 4 weeks. Weekly follow-up visits were required during which patients received repeat weight, blood pressure, and medical evaluation. Blood tests were conducted every 2 weeks for electrolyte, hormone, and lipid monitoring. Of the subjects, there were 30 HCG and 29 Placebo. Six subjects dropped out in each group. In the placebo group, five were noncompliant and one had a starting BMI less than 25, and thus were eliminated from analysis. In the HCG group, three were noncompliant (weight loss less than 5 lbs or extreme outlier (1) and one had a starting BMI less than 25, and thus were eliminated from analysis. Median weight loss achieved in each group was 14 pounds. The mean was 14 pounds in HCG and 15 pounds in placebo. Median fat loss was 11 pounds in HCG, 9.2 in placebo Median muscle loss was 3.2 in HCG and 4.8 in placebo. The means were 2.7 and 5.4, respectively</p><p></p><p>ANALYSIS: Mann-Whitney U Test Median Comparison: HCG vs. placebo. Primary endpoint: weight change. Secondary endpoints: change in muscle mass and change in fat mass. RESULTS: PRIMARY: no significant difference in weight loss between the two groups (p=0.5521), SECONDARY: Comparison of fat mass loss was not significant, with a p of 0.4189. <strong>Comparison of muscle mass loss was significant at a p-value of 0.0303 with the HCG group retaining more muscle. </strong>As was expected, on a 500 calorie diet, nearly equivalent amounts of weight will be lost. The difference is in that the body will preferentially burn fat for energy and protect muscle in the HCG group versus the placebo group.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 136226, member: 3"] [B]HCG Injections in a Randomized, Double-Blinded, Placebo-Controlled Trial[/B] [URL='http://dremma.com/wp-content/uploads/2016/11/SE-Poster-Final.pdf']Source[/URL] Four week trials were conducted on a total of [B]59 females [/B]between the ages of 20 and 55, with no major medical illness. They were placed on a 500 calorie diet (50% protein). Measured parameters: weight, body composition via bioimpedance, blood pressure, and blood labs were performed. Subjects received daily hCG or saline (placebo) subcutaneous injections. After 4 weeks, the subjects body compositions were analyzed for overall change. There was significantly more muscle lost in the placebo group versus the HCG group. Overall weight loss was similar between the two groups. This lends support to the theory that HCG is acting to preserve lean body mass during a calorie deprived state. 59 females were randomized to HCG or Placebo Study Groups. All subjects were between the ages of 20 and 55, with no major medical conditions. Recorded variables: weight, body composition, blood pressure, blood labs (CBC, complete metabolic panel, thyroid panel, hormones, and B-HCG), and in some patients, EKG. All were placed on a 500 calorie diet (approximately 50% protein) and were instructed to keep a diary of progress, hunger, and a food log. Subjects were randomized to HCG or placebo (saline) and injected between 200 and 300 IU subcutaneously daily for 4 weeks. Weekly follow-up visits were required during which patients received repeat weight, blood pressure, and medical evaluation. Blood tests were conducted every 2 weeks for electrolyte, hormone, and lipid monitoring. Of the subjects, there were 30 HCG and 29 Placebo. Six subjects dropped out in each group. In the placebo group, five were noncompliant and one had a starting BMI less than 25, and thus were eliminated from analysis. In the HCG group, three were noncompliant (weight loss less than 5 lbs or extreme outlier (1) and one had a starting BMI less than 25, and thus were eliminated from analysis. Median weight loss achieved in each group was 14 pounds. The mean was 14 pounds in HCG and 15 pounds in placebo. Median fat loss was 11 pounds in HCG, 9.2 in placebo Median muscle loss was 3.2 in HCG and 4.8 in placebo. The means were 2.7 and 5.4, respectively ANALYSIS: Mann-Whitney U Test Median Comparison: HCG vs. placebo. Primary endpoint: weight change. Secondary endpoints: change in muscle mass and change in fat mass. RESULTS: PRIMARY: no significant difference in weight loss between the two groups (p=0.5521), SECONDARY: Comparison of fat mass loss was not significant, with a p of 0.4189. [B]Comparison of muscle mass loss was significant at a p-value of 0.0303 with the HCG group retaining more muscle. [/B]As was expected, on a 500 calorie diet, nearly equivalent amounts of weight will be lost. The difference is in that the body will preferentially burn fat for energy and protect muscle in the HCG group versus the placebo group. [/QUOTE]
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The HCG Diet: Does It Work?
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