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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Testosterone (or Anastrozole?) Decreased my HDL: What Can I Do?
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<blockquote data-quote="johndoesmith" data-source="post: 70852" data-attributes="member: 13404"><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371249/" target="_blank">Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity</a></p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/8678922" target="_blank">Effect of testosterone replacement therapy on lipids and lipoproteins in hypogonadal and elderly men. - PubMed - NCBI</a></p><p></p><p>I'm sorry, but evidence doesn't support this.</p><p></p><p></p><p></p><p>Alternative <a href="https://en.wikipedia.org/wiki/Route_of_administration" target="_blank">routes of administration</a> like <a href="https://en.wikipedia.org/wiki/Suppository" target="_blank">suppository</a>, <a href="https://en.wikipedia.org/wiki/Intravenous" target="_blank">intravenous</a>, <a href="https://en.wikipedia.org/wiki/Intramuscular" target="_blank">intramuscular</a>, inhalational aerosol, transdermal and <a href="https://en.wikipedia.org/wiki/Sublingual" target="_blank">sublingual</a> avoid the first-pass effect because they allow drugs to be absorbed directly into the <a href="https://en.wikipedia.org/wiki/Systemic_circulation" target="_blank">systemic circulation</a>.</p><p></p><p><a href="https://en.wikipedia.org/wiki/First_pass_effect" target="_blank">First pass effect - Wikipedia</a></p><p></p><p>Are you telling me you believe parenteral administration of a drug undergoes first pass metabolism?</p><p></p><p>You also believe that esters are cleaved hepatically?</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782087/" target="_blank">Critical Factors Influencing the In Vivo Performance of Long-acting Lipophilic Solutions—Impact on In Vitro Release Method Design</a></p></blockquote><p></p>
[QUOTE="johndoesmith, post: 70852, member: 13404"] [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371249/"]Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity[/URL] [URL="https://www.ncbi.nlm.nih.gov/pubmed/8678922"]Effect of testosterone replacement therapy on lipids and lipoproteins in hypogonadal and elderly men. - PubMed - NCBI[/URL] I'm sorry, but evidence doesn't support this. Alternative [URL='https://en.wikipedia.org/wiki/Route_of_administration']routes of administration[/URL] like [URL='https://en.wikipedia.org/wiki/Suppository']suppository[/URL], [URL='https://en.wikipedia.org/wiki/Intravenous']intravenous[/URL], [URL='https://en.wikipedia.org/wiki/Intramuscular']intramuscular[/URL], inhalational aerosol, transdermal and [URL='https://en.wikipedia.org/wiki/Sublingual']sublingual[/URL] avoid the first-pass effect because they allow drugs to be absorbed directly into the [URL='https://en.wikipedia.org/wiki/Systemic_circulation']systemic circulation[/URL]. [URL="https://en.wikipedia.org/wiki/First_pass_effect"]First pass effect - Wikipedia[/URL] Are you telling me you believe parenteral administration of a drug undergoes first pass metabolism? You also believe that esters are cleaved hepatically? [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782087/"]Critical Factors Influencing the In Vivo Performance of Long-acting Lipophilic Solutions—Impact on In Vitro Release Method Design[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Testosterone (or Anastrozole?) Decreased my HDL: What Can I Do?
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