Testosterone levels keep dropping

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HealthMan

Member
I have been using the same protocol for a while and my testosterone levels keep dropping but my RBC, Hemoglobin and hematocrit going up (i used to donate blood every 2-3 months but stopped to see if hematocrit would stabilize - i wasnt expecting raising lvls with testosterone dropping)
I am using 56mg testosterone cypionate every 3.5D, HCG 500 IU 3x a week and 0.25mg anastrozole E4D. Blood drawn at the same day and around same time (on the day of T-shot but BEFORE the shot).

Any idea why testosterone keeps dropping? And can a tiny change in testosterone dosage (from 60mg to 54mg E3.5D) be responsible for such a difference in testosterone levels in the labs below?

Lab Results:
May/19/17

RBC 6 (range 4.14-5.8)
Hemoglobin 17.8 (range 12.6-17.7)
Hematocrit 52.4 (range 37.5-51)
Total Testosterone 770 (range 348-1197)
Free testosterone 21.8 (range 8.7-25.1)
SHBG 26.2 (range 16.5-55.9)
Estradiol sensitive 17.5 (range 8-35)

Jan/18/17

RBC 5.64 (range 4.14-5.8)
Hemoglobin 16.6 (range 12.6-17.7)
Hematocrit 49.4 (range 37.5-51)
Total Testosterone 892 (range 348-1197)
Free testosterone 30.3 (range 8.7-25.1)
SHBG 21.7 (range 16.5-55.9)
Estradiol sensitive 18.4 (range 8-35)

Dec/19/16 (cypionate dosage here was 60mg E3.5D and anastrozole 0.25mg three time a week)

RBC 5.89 (range 4.14-5.8)
Hemoglobin 17.2 (range 12.6-17.7)
Hematocrit 51.7 (range 37.5-51)
Total Testosterone 1298 (range 348-1197)
Free testosterone 36.1 (range 8.7-25.1)
SHBG 36.5 (range 16.5-55.9)
Estradiol sensitive 11.3 (range 8-35)
 
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HealthMan

Member
Forgot to mention on january 2017 i started metformin 500mg twice a day. I heard metformin can reduce testosterone levels (but i dont know of same applies for someone on TRT)
 

HealthMan

Member
Yes. Estradio has been a challenge to get it right. And i had gynecomastia because of that so playing safe. But have been reducing dosage from 3 a week to E3D to E4D. I am wondering if metformin is the culprit of lowering T-levels or it is my body metabolizing testosterone quicker. But that doesnt seem to make sense too because i started metforming on jan/14/17 and had blood work done jan/18/17 so only 4 days
 
Just to cover the bases and a dose change aside, if you're not pulling labs very consistently from one-time to the next you'll get varied results, obviously. For instance I only pull labs between 8 and 830 and +/- 1 hour difference from my last injection. If one set of labs is 4hours off from the last set, it's enough to skew a result. And ayour 1298 is obviously not a trough number, that's my point here....you're testing times and strategy are questionable.
 

HealthMan

Member
Just to cover the bases and a dose change aside, if you're not pulling labs very consistently from one-time to the next you'll get varied results, obviously. For instance I only pull labs between 8 and 830 and +/- 1 hour difference from my last injection. If one set of labs is 4hours off from the last set, it's enough to skew a result. And ayour 1298 is obviously not a trough number, that's my point here....you're testing times and strategy are questionable.

Hi Vince. I am testing evey Tuesday morning (from 7-8am every single time). I inject testosterone tuesday night and Saturday morning. hCG i take M W F night. So i have been very consistent im regards to blood drawing timing. The 1298 result my dosage was a bit high (60mg 2x week vs 56mg 2x week). So that i can guarantee you i am doing right. Injection time varies a bit because sometimes i get home later because of my job. But usually within 2 hours.
 

Vince

Super Moderator
Yes. Estradio has been a challenge to get it right. And i had gynecomastia because of that so playing safe. But have been reducing dosage from 3 a week to E3D to E4D. I am wondering if metformin is the culprit of lowering T-levels or it is my body metabolizing testosterone quicker. But that doesnt seem to make sense too because i started metforming on jan/14/17 and had blood work done jan/18/17 so only 4 days

Are you using Tamoxifen for your gynecomastia.
 

madman

Super Moderator
shbg range 16.5-55.9 so mid point would be 36.2 on 12/9/16 your shbg was 36.5 and 1/18/17 was 21.7 quite a drop and 5/19/17 was 26.2 slightly up but still below mid range if your numbers are accurate maybe you are metabolizing test quicker.
 

HealthMan

Member
shbg range 16.5-55.9 so mid point would be 36.2 on 12/9/16 your shbg was 36.5 and 1/18/17 was 21.7 quite a drop and 5/19/17 was 26.2 slightly up but still below mid range if your numbers are accurate maybe you are metabolizing test quicker.

Forgot to mention but when my SHBG was 36.2 i was taking tamoxifen (which has shown to increase SHBG). On the labwork before that without tamoxifen and 70mg testosterone cypionate E3.5D my SHBG was 25.3 and total testosterone 1331 so i dont think this is the problem. I dont know.
When i felt my best was when my total T was 1200-1300 area but I was worried about hematocrit. Now with total T around 700-800 i dont feel as nearly as good and still have hematocrit issues. I think the best thing would be to go back to old protocol using 70mg E3.5D
 

HealthMan

Member
Aug/29/16 bloodwork results (70mg testosterone cypionate E3.5D and 0.25mg anastrozole E3.5D)

RBC 5.76 (range 4.14-5.8)
Hemoglobin 17 (range 12.6-17.7)
Hematocrit 51.7 (range 37.5-51)
Total Testosterone 1331 (range 348-1197)
Free testosterone 35.6 (range 8.7-25.1)
SHBG 25.3 (range 16.5-55.9)
Estradiol sensitive 37.5 (range 8-35)
 
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