Testosterone cream applied on genitals

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Vince

Super Moderator
In two weeks I’m meeting with an anti-aging doctor who will most probably prescribe me testosterone cream. The reason I want to try TRT is to cure my erectile dysfunction, which I’ve had ever since I became sexually active 15 years ago.

I don’t know the details yet, because she’s waiting for my blood tests results before to prescribe anything. But she looked at some tests I made in the past, and she said that my testosterone was too low for someone my age and that she would probably prescribe testosterone.

She suggested that I put the cream directly on my genitals. My question is, does that make any sense? I know it might sound very vague, because I’m not giving enough details. I’ll come back on this forum to post those details when I get my prescription in two weeks, but in the meantime, I’m trying to find out if what she suggested makes sense or not.
 

S1W

Well-Known Member
Yes, that is common. On your scrotum, not your penis.

Also, ask your doc to prescribe you 5mg daily Tadalafil too. In fact, I would not take no for an answer on this...not that they’d have any reason to say no.
 

Dicky

Active Member
She suggested that I put the cream directly on my genitals. My question is, does that make any sense? I know it might sound very vague, because I’m not giving enough details. I’ll come back on this forum to post those details when I get my prescription in two weeks, but in the meantime, I’m trying to find out if what she suggested makes sense or not.
I love using T cream. To a large extent I can control my libido with it. If I want to be more horny, I rub more of my cream dose on my scrotum. If my libido is getting to be too much, I rub the cream elsewhere on my body. The theory is that cream applied to your scrotum ends up producing more DHT in your body. DHT is known to increase libido.
Note that I also inject a low dose of testosterone cypionate (40mg/week). It seems to help me feel better to have a baseline level of cypionate in my system at all times. I used to only use injections only. I started using cream because it produces more estrogen in me than injections do. For whatever reason, I was low E2, even on exogenous testosterone. Just for clarity, I reduced the amount of cypionate I used when I introduced cream into the mix.
 
Thanks a lot. Glad to see it actually makes sense, and that putting cream on the scrotum seems pretty common.

I’ve been using Viagra for years and it works very well. I don’t know if daily Cialis will do the trick, because it’s a lower dose, but I’ll definitely keep that in mind. It would be nice, though, it would allow me to have a more spontaneous sex life.
Cialis/Tadalafil is a long acting medicine that stays in your system 24 to 36 hours whereas Viagra/Sidenafil is quick acing and lasts up to 4 hours. I taken 10mg of Tadalafil in the morning and 100mg of Sidenafil a night if I am going to be sexually active. Sometimes they work most times they leave me hanging ... no pun intended.
 

camygod

Active Member
I love using T cream. To a large extent I can control my libido with it. If I want to be more horny, I rub more of my cream dose on my scrotum. If my libido is getting to be too much, I rub the cream elsewhere on my body. The theory is that cream applied to your scrotum ends up producing more DHT in your body. DHT is known to increase libido.
Note that I also inject a low dose of testosterone cypionate (40mg/week). It seems to help me feel better to have a baseline level of cypionate in my system at all times. I used to only use injections only. I started using cream because it produces more estrogen in me than injections do. For whatever reason, I was low E2, even on exogenous testosterone. Just for clarity, I reduced the amount of cypionate I used when I introduced cream into the mix.
how often do you inject the cyp?
 

Cooper

Member
I love using T cream. To a large extent I can control my libido with it. If I want to be more horny, I rub more of my cream dose on my scrotum. If my libido is getting to be too much, I rub the cream elsewhere on my body. The theory is that cream applied to your scrotum ends up producing more DHT in your body. DHT is known to increase libido.
Note that I also inject a low dose of testosterone cypionate (40mg/week). It seems to help me feel better to have a baseline level of cypionate in my system at all times. I used to only use injections only. I started using cream because it produces more estrogen in me than injections do. For whatever reason, I was low E2, even on exogenous testosterone. Just for clarity, I reduced the amount of cypionate I used when I introduced cream into the mix.
how many clicks per day and do you apply all in morning or split into 2 doses?
 

Rentner2022

New Member
I love using T cream. To a large extent I can control my libido with it. If I want to be more horny, I rub more of my cream dose on my scrotum. If my libido is getting to be too much, I rub the cream elsewhere on my body. The theory is that cream applied to your scrotum ends up producing more DHT in your body. DHT is known to increase libido.
Note that I also inject a low dose of testosterone cypionate (40mg/week). It seems to help me feel better to have a baseline level of cypionate in my system at all times. I used to only use injections only. I started using cream because it produces more estrogen in me than injections do. For whatever reason, I was low E2, even on exogenous testosterone. Just for clarity, I reduced the amount of cypionate I used when I introduced cream into the mix.
Can i ask you how you made the switch? What was your substitution ratio? I (54M) am currently taking 130 Test Cyp a week but want to try scrotal cream to see if it is better at relieving libido symptoms. Currently 130 TC/wk (split 3x) puts me at about the right overall level (TT at 1000, free T at 25, E2 sensitive at 34). But I don't want to switch entirely, I want to move to a split protocol.

So here's what I was thinking- if one click is .25 ml and it's a 50 mg/ml cream, then that's 12.5 Test per click. At a 50% absorption rate that 6 mg Test absorbed per click. 130 mg/wk injected is 18.5 mg/day. I think TC is about 70% Test so that's 13 mg Test/day. So if I wanted to start with a split protocol adding one click a day of cream means I can cut my TC injections by half (to say maybe 70 mg/wk)?

Is that similar to what you did?
 

madman

Super Moderator
Absorption is ridiculous on the scrotum cream for me. 4 clicks of 20%, my free T is 3 times higher than even 200mg cyp weekly.

Your FT will be even higher as unfortunately, you did not use the TT (LC/MS-MS).

Most likely hitting TT 1500-2000 ng/dL.

You tested 8 hours post-application.

Trough levels will most likely be high.

The most accurate assay for TT (LC/MS-MS) should always be alongside FT (Equilibrium Dialysis or Ultrafiltration).
 
Z

Zibernet

Guest
Your FT will be even higher as unfortunately, you did not use the TT (LC/MS-MS).

Most likely hitting TT 1500-2000 ng/dL.

You tested 8 hours post-application.

Trough levels will most likely be high.

The most accurate assay for TT (LC/MS-MS) should always be alongside FT (Equilibrium Dialysis or Ultrafiltration).

All bloods should be done at trough, ie 12 hours post application if applying twice a day.
 

madman

Super Moderator
All bloods should be done at trough, ie 12 hours post application if applying twice a day.

Most definitely.

He is applying once daily.

Top it off that even if he were to test at true trough whether once/twice daily application
we would have no clue where his FT truly sits unless he tested TT (LC/MS-MS).

Although he used one of the most accurate assays for FT (Equilibrium Ultrafiltration) his TT was not tested using the most accurate assay (LC/MS-MS) and as you can see his lab value capped out at >1500 ng/dL.
 
Last edited:

DixieWrecked

Well-Known Member
Most definitely.

He is applying once daily.

Top it off that even if he were to test at true trough whether once/twice daily application
we would have no clue where his FT truly sits unless he tested TT (LC/MS-MS).

Although he used one of the most accurate assays for FT (Equilibrium Ultrafiltration) his TT was not tested using the most accurate assay (LC/MS-MS) and as you can see his lab value capped out at >1500 ng/dL.
Yes I know. Would be interesting to see how high it actually went. Might do that at some point.
 

DixieWrecked

Well-Known Member
All bloods should be done at trough, ie 12 hours post application if applying twice a day.
Yes, yes. I know. I'll do that probably this summer when my work schedule and the lab hours allow for it. For now, this was the best I can do. At that time I'll get the LC/MS-MS done.
 

vandar100

New Member
In two weeks I’m meeting with an anti-aging doctor who will most probably prescribe me testosterone cream. The reason I want to try TRT is to cure my erectile dysfunction, which I’ve had ever since I became sexually active 15 years ago.

I don’t know the details yet, because she’s waiting for my blood tests results before to prescribe anything. But she looked at some tests I made in the past, and she said that my testosterone was too low for someone my age and that she would probably prescribe testosterone.

She suggested that I put the cream directly on my genitals. My question is, does that make any sense? I know it might sound very vague, because I’m not giving enough details. I’ll come back on this forum to post those details when I get my prescription in two weeks, but in the meantime, I’m trying to find out if what she suggested makes sense or not.
I have been using a cream for years, originally on my upper arms and elbow creases. Absorbstion was a problems. I now put it on my scrotum and shaft daily. My test results after 3-4 hours after application is in the 1300-1500 range. I use a compound pharmacy and have had good luck, especially since it is a natural plant based medication. Skin irritation mat be a problem but the pharmacist can change the base cream.There is a lot of blood vessels and thin skin down there so absorption is great. It works for me. Only drawback is that my spouse can't touch me there or else she'll start growing a beard.
 
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