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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
tapering off clomid after 9 months
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<blockquote data-quote="Cataceous" data-source="post: 223826" data-attributes="member: 38109"><p>It's true that typical guidelines do not call for a taper when stopping clomiphene. The issue brings up an interesting question: Is there a suppressive rebound caused by the subsequent dominance of zuclomiphene? Clomiphene is composed of enclomiphene and zuclomiphene. Enclomiphene is the anti-estrogen that stimulates the HPTA. It has a short half-life, under half a day. Zuclomiphene is estrogenic, and when taken alone is capable of shutting down a normal HPTA. Zuclomiphene has a very long half-life, perhaps on the order of 30 days. Therefore, when clomiphene is discontinued the enclomiphene is active for a few days at most, while the suppressive zuclomiphene persists for months.</p><p></p><p>Even if this is what happens, I'm doubtful a taper would improve matters. The zuclomiphene you take in is always going to far outlast the enclomiphene. Better would be to switch to pure enclomiphene and taper with that until the zuclomiphene is gone. Best would be to use pure enclomiphene from the start, avoiding the confounding influence of zuclomiphene.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 223826, member: 38109"] It's true that typical guidelines do not call for a taper when stopping clomiphene. The issue brings up an interesting question: Is there a suppressive rebound caused by the subsequent dominance of zuclomiphene? Clomiphene is composed of enclomiphene and zuclomiphene. Enclomiphene is the anti-estrogen that stimulates the HPTA. It has a short half-life, under half a day. Zuclomiphene is estrogenic, and when taken alone is capable of shutting down a normal HPTA. Zuclomiphene has a very long half-life, perhaps on the order of 30 days. Therefore, when clomiphene is discontinued the enclomiphene is active for a few days at most, while the suppressive zuclomiphene persists for months. Even if this is what happens, I'm doubtful a taper would improve matters. The zuclomiphene you take in is always going to far outlast the enclomiphene. Better would be to switch to pure enclomiphene and taper with that until the zuclomiphene is gone. Best would be to use pure enclomiphene from the start, avoiding the confounding influence of zuclomiphene. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
tapering off clomid after 9 months
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