T-cream Scrotal, shocking bloodwork

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eli

Active Member
So Ive been on 100mg of T-cream a day for 10 days or so decide to get bloodwork done. The results are great but weird.

Protocol 50mg AM and PM. Blood work 4-5 hours after 50mg T was applied on scrotum
Blood work:

TT 730
FT 26
E2 21
SHBG 10

The weird part is, when I did SubQ like 50mg e3.5d, I'd have a much lower TT like 400-500 and much higher E2 like in high 30s. About the same SHBG and FT

I have to say I feel much better this way but now I'm wondering if SubQ made me aromatase more, maybe the frequency of T cream makes me aromatase less? Why is Total T almost twice higher than with T-cream than injections? So confused about this, maybe didn't absorb SubQ well? All I know is that Total T should have stayed similar and FT or E2 numbers been volitale
 
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Systemlord

Member
You point out you've only been on the T cream for 10 days, it would be interesting to see where you are in 6 weeks. Also on injections your levels are more stable whereas on creams your levels fluctuate more probably leading to less aromatisation.

Two injections a week is hardly optimal for such low SHBG levels, I would have recommended daily injections. If 50mg twice weekly got your E2 in the high 30's, EOD and even daily would have seen E2 much lower.
 
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eli

Active Member
You point out you've only been on the T cream for 10 days, it would be interesting to see where you are in 6 weeks. Also on injections your levels are more stable whereas on creams your levels fluctuate more probably leading to less aromatisation.

Two injections a week is hardly optimal for such low SHBG levels, I would have recommended daily injections. If 50mg twice weekly got your E2 in the high 30's, EOD and even daily would have seen E2 much lower.

To be honest with you, I'd rather do the cream daily than the injection ED. one click gives me the 50mg (200mg/ml - 4clicks), it's a tiny amount. I use the container to rub it on my scrotum and do that again in 6 hours. I don't touch anything and it takes a minute and if I had kids or was married, it wouldn't get on anyone.

I will try 100mg at once in a few weeks to see if that works, it'd be even better
 

Cataceous

Super Moderator
So Ive been on 100mg of T-cream a day for 10 days or so decide to get bloodwork done. The results are great but weird.

Protocol 50mg AM and PM. Blood work 4-5 hours after 50mg T was applied on scrotum
...
The weird part is, when I did SubQ like 50mg e3.5d, I'd have a much lower TT like 400-500 and much higher E2 like in high 30s. About the same SHBG and FT

I have to say I feel much better this way but now I'm wondering if SubQ made me aromatase more, maybe the frequency of T cream makes me aromatase less? Why is Total T almost twice higher than with T-cream than injections? So confused about this, maybe didn't absorb SubQ well? All I know is that Total T should have stayed similar and FT or E2 numbers been volitale
With T (cypionate?) you were getting about 70 mg per week of testosterone. Transdermal testosterone applied to the scrotum can be absorbed far more efficiently than when applied to other skin. Absorption efficiencies of up to 60% have been reported. Clearly you're not absorbing 400+ mg/week, but even at 20% absorption you'd be getting twice as much testosterone as you were with injections.

There are various possible explanations for the lower estradiol. One is that the test is wrong. If this happens to be LabCorp's sensitive test then I can report that for me it has been grossly wrong a third of the time. The standard free T test is also going to be unreliable.

There are some reports that DHT has aromatase-inhibiting properties. If this is the case then perhaps you have high DHT from the scrotal application. Regardless, it's still advisable to test this hormone sooner or later.
 
Yes would like to see you add DHT labs in the future if it's affordable for you. I think that trying to correlated injections and cream response is just futile.
 

S1W

Well-Known Member
So Ive been on 100mg of T-cream a day for 10 days or so decide to get bloodwork done. The results are great but weird.

The weird part is, when I did SubQ like 50mg e3.5d, I'd have a much lower TT like 400-500 and much higher E2 like in high 30s. About the same SHBG and FT

It may not be an apples to apples comparison because you tested cream results near peak, and although you didn't mention when you tested on injections, people typically test at or near trough. With your SHBG, I bet your peak TT on E3.5D injections was significantly higher than your trough.

If you have the cash and happen to enjoy getting your blood drawn, it might surprise you to test in the morning before you apply your AM cream. I found the my levels fluctuated a lot more on cream. Although I was on 1x/day cream, so your results may vary.

My E2 was also a bit lower on cream but my TT also never got as high as it did with injections.

Happy to hear you feel good on it!
 
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Tman

Active Member
So Ive been on 100mg of T-cream a day for 10 days or so decide to get bloodwork done. The results are great but weird.

Protocol 50mg AM and PM. Blood work 4-5 hours after 50mg T was applied on scrotum
Blood work:

TT 730
FT 26
E2 21
SHBG 10

The weird part is, when I did SubQ like 50mg e3.5d, I'd have a much lower TT like 400-500 and much higher E2 like in high 30s. About the same SHBG and FT

I have to say I feel much better this way but now I'm wondering if SubQ made me aromatase more, maybe the frequency of T cream makes me aromatase less? Why is Total T almost twice higher than with T-cream than injections? So confused about this, maybe didn't absorb SubQ well? All I know is that Total T should have stayed similar and FT or E2 numbers been volitale


I don't think it's weird; I think you are trying to compare apples and oranges... I was on 60 mgs of Testogel and my T was 1400 2 hours later. The problem with gel, 24 hours later I was back to baseline.
OR, I definitely would of stayed with the gels.
Creams/gels can give you great T numbers, but their longevity/predictability is the issue.
 

eli

Active Member
@eli
How do you feel on the cream? Mood and libido?
Im also switching to scrotal cream in a few weeks.

Everything is great so far

I don't think it's weird; I think you are trying to compare apples and oranges... I was on 60 mgs of Testogel and my T was 1400 2 hours later. The problem with gel, 24 hours later I was back to baseline.
OR, I definitely would of stayed with the gels.
Creams/gels can give you great T numbers, but their longevity/predictability is the issue.

That's why I do AM and PM. No problems so far, maybe going half injection half cream would be even better
 
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