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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Should I consider T replacement?
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<blockquote data-quote="Cataceous" data-source="post: 233987" data-attributes="member: 38109"><p>The unmentioned caveat is that correlation does not prove causality. In this context one must also consider free testosterone and SHBG. Free testosterone is considerably more important than total testosterone when it comes to the effects of testosterone. Lower SHBG artificially reduces total testosterone without affecting free testosterone. Therefore this study could be reflecting a risk linked to lower SHBG. Lower SHBG is correlated with metabolic syndrome, for one.</p><p></p><p>For a more balanced take, read here:</p><p>[URL unfurl="true"]https://www.excelmale.com/testosterone-dht-and-estradiol-and-mortality-in-older-men/[/URL]</p><p style="margin-left: 20px"><em>Our results challenge the concept that lower T is associated with increased mortality in a linear fashion. Instead, an optimal range of circulating total T corresponding to a range of 9.8 to 15.8 nmol/L (<strong>282–455 ng/dL</strong>) exists for older men, which predicts survival independent of other risk factors.</em></p><p></p><p>What's interesting is that their graph shows mortality bottoming out when free testosterone is 200 pMol/L, which is 5.8 ng/dL. In comparison, your Vermeulen free testosterone is 12.4 ng/dL. In my opinion this value is into the healthy normal range. I would avoid TRT—but if you want to find out if higher testosterone would be beneficial then run a trial with a testosterone nasal gel such as Natesto. This has the advantage of causing less overall disruption to your hormones than conventional TRT.</p><p></p><p>By the way, do you have the same moniker on PeakTestosterone? Unfortunately the owner(s) of that site seem to have lost interest in keeping it going.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 233987, member: 38109"] The unmentioned caveat is that correlation does not prove causality. In this context one must also consider free testosterone and SHBG. Free testosterone is considerably more important than total testosterone when it comes to the effects of testosterone. Lower SHBG artificially reduces total testosterone without affecting free testosterone. Therefore this study could be reflecting a risk linked to lower SHBG. Lower SHBG is correlated with metabolic syndrome, for one. For a more balanced take, read here: [URL unfurl="true"]https://www.excelmale.com/testosterone-dht-and-estradiol-and-mortality-in-older-men/[/URL] [INDENT][I]Our results challenge the concept that lower T is associated with increased mortality in a linear fashion. Instead, an optimal range of circulating total T corresponding to a range of 9.8 to 15.8 nmol/L ([B]282–455 ng/dL[/B]) exists for older men, which predicts survival independent of other risk factors.[/I][/INDENT] What's interesting is that their graph shows mortality bottoming out when free testosterone is 200 pMol/L, which is 5.8 ng/dL. In comparison, your Vermeulen free testosterone is 12.4 ng/dL. In my opinion this value is into the healthy normal range. I would avoid TRT—but if you want to find out if higher testosterone would be beneficial then run a trial with a testosterone nasal gel such as Natesto. This has the advantage of causing less overall disruption to your hormones than conventional TRT. By the way, do you have the same moniker on PeakTestosterone? Unfortunately the owner(s) of that site seem to have lost interest in keeping it going. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Should I consider T replacement?
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