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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
SHBG cause or consequence of hypogonadism?
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<blockquote data-quote="Cataceous" data-source="post: 229956" data-attributes="member: 38109"><p>For me it was the realization that conventional wisdom is incompatible with a couple very basic assumptions. <a href="https://www.excelmale.com/forum/threads/freeing-up-testosterone-with-average-t-levels-and-or-higher-shbg.25063/post-220663" target="_blank">Here's</a> one of the posts where I lay out the reasoning.</p><p></p><p style="margin-left: 20px">The working hypothesis is that in steady state conditions free testosterone is directly proportional to the production rate of endogenous testosterone, or to the dose rate of exogenous testosterone. Only two primary assumptions are necessary: 1) The rate of testosterone entering the system is matched by the rate of testosterone being metabolized and eliminated. 2) The rate of metabolism and elimination is proportional to the level of free testosterone, following the <a href="https://en.wikipedia.org/wiki/Law_of_mass_action" target="_blank">law of mass action</a>. A secondary assumption is that the underlying rate constant for metabolic clearance is relatively static. There are situations in which this constant changes dramatically, presumably including damage to the liver. But we'd hope these would not be common.</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">If the hypothesis is correct then it's clear that SHBG has little effect on free testosterone. Also, there are so many factors affecting the production rate of SHBG that it probably could not serve as a viable regulator anyway. And SHBG has a half-life of about a week, so it would be a very slow regulator as well.</p><p></p><p></p><p>Just in the last year you referenced a paper that mentioned this hypothesis in plain language. I'm sure I saved it, but I have so many I'll have trouble identifying it. In any case, while I arrived at the idea independently, it's not as though I'm the only one who found it to be a logical progression.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 229956, member: 38109"] For me it was the realization that conventional wisdom is incompatible with a couple very basic assumptions. [URL='https://www.excelmale.com/forum/threads/freeing-up-testosterone-with-average-t-levels-and-or-higher-shbg.25063/post-220663']Here's[/URL] one of the posts where I lay out the reasoning. [INDENT]The working hypothesis is that in steady state conditions free testosterone is directly proportional to the production rate of endogenous testosterone, or to the dose rate of exogenous testosterone. Only two primary assumptions are necessary: 1) The rate of testosterone entering the system is matched by the rate of testosterone being metabolized and eliminated. 2) The rate of metabolism and elimination is proportional to the level of free testosterone, following the [URL='https://en.wikipedia.org/wiki/Law_of_mass_action']law of mass action[/URL]. A secondary assumption is that the underlying rate constant for metabolic clearance is relatively static. There are situations in which this constant changes dramatically, presumably including damage to the liver. But we'd hope these would not be common.[/INDENT] [INDENT][/INDENT] [INDENT]If the hypothesis is correct then it's clear that SHBG has little effect on free testosterone. Also, there are so many factors affecting the production rate of SHBG that it probably could not serve as a viable regulator anyway. And SHBG has a half-life of about a week, so it would be a very slow regulator as well.[/INDENT] Just in the last year you referenced a paper that mentioned this hypothesis in plain language. I'm sure I saved it, but I have so many I'll have trouble identifying it. In any case, while I arrived at the idea independently, it's not as though I'm the only one who found it to be a logical progression. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
SHBG cause or consequence of hypogonadism?
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