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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
SHBG cause or consequence of hypogonadism?
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<blockquote data-quote="Cataceous" data-source="post: 229717" data-attributes="member: 38109"><p>There's no need for higher testosterone production. Think of production as equaling free testosterone. At steady state the amount of SHBG is basically irrelevant. Someone recently suggested a sponge analogy: SHBG is likened to a sponge, with testosterone being the water. Testosterone—water—is dripped onto the sponge. This represents production. When the sponge is saturated the testosterone drips off the bottom of the sponge—this represents free testosterone being used. At steady state the flow of testosterone leaving the sponge equals the production entering the sponge. You can double the size of the sponge—the amount of SHBG—which temporarily reduces the flow, but the sponge soon saturates again so that outflow again equals inflow. A larger sponge means more total testosterone is contained within the sponge. But that testosterone within the sponge isn't doing much of anything, and so is largely irrelevant. For the sake of simplicity this ignores the possible benefits in having testosterone buffered this way.</p><p></p><p>A little more detail on the transient effect: Think of the body as regulating production to attain its desired outflow. If you could instantly enlarge the sponge—increase SHBG—then the body detects the reduced outflow and increases production. But the sponge soon saturates and outflow even goes too high, leading to reduced production. There could even be damped oscillations. But over time the flow rates return to where they started.</p><p></p><p></p><p>As illustrated in the above analogy, once the SHBG is "saturated" by the flow of testosterone the amount of SHBG and total testosterone doesn't much matter.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 229717, member: 38109"] There's no need for higher testosterone production. Think of production as equaling free testosterone. At steady state the amount of SHBG is basically irrelevant. Someone recently suggested a sponge analogy: SHBG is likened to a sponge, with testosterone being the water. Testosterone—water—is dripped onto the sponge. This represents production. When the sponge is saturated the testosterone drips off the bottom of the sponge—this represents free testosterone being used. At steady state the flow of testosterone leaving the sponge equals the production entering the sponge. You can double the size of the sponge—the amount of SHBG—which temporarily reduces the flow, but the sponge soon saturates again so that outflow again equals inflow. A larger sponge means more total testosterone is contained within the sponge. But that testosterone within the sponge isn't doing much of anything, and so is largely irrelevant. For the sake of simplicity this ignores the possible benefits in having testosterone buffered this way. A little more detail on the transient effect: Think of the body as regulating production to attain its desired outflow. If you could instantly enlarge the sponge—increase SHBG—then the body detects the reduced outflow and increases production. But the sponge soon saturates and outflow even goes too high, leading to reduced production. There could even be damped oscillations. But over time the flow rates return to where they started. As illustrated in the above analogy, once the SHBG is "saturated" by the flow of testosterone the amount of SHBG and total testosterone doesn't much matter. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
SHBG cause or consequence of hypogonadism?
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