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Sermorelin
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<blockquote data-quote="BigTex" data-source="post: 224395" data-attributes="member: 43589"><p>The problem with using any GHRH (sermorelin) even the stronger analogs as a stand alone is that they are only highly effective when somatostatin is low. Remember somatostatin is the GH inhibitory hormone. So if you unluckily administer in a trough (somatostatin is high) you will add very little GH release. If you luckily enough to administer during a rising wave or GH pulse when somatostatin is low you will add to GH release. This true no matter what analog of GHRH you use, which is why you need to add a GHRP. The GHRP (eg. Ipamorelin) reduces somatostatin making the Sermorelin much more effective as it increases GH pulse. Further the lack of somatostatin will cause a positive effect on the pituitary further increasing you natural level of GHRH with further increases you natural pulse of GH. So the two have a very synergistic effect on the actions of each peptide.</p><p></p><p>By using Ipamorelin with Sermorelin you greatly increase the body's natural GH pulse by lowering somatostatin. GH has the ability to stimulate lipolysis or the release of fat stores the more GH you produce the more you stimulate lipolysis. This same effect will happen using GHRP 2, GHRP 6 or even Hexarelin.</p></blockquote><p></p>
[QUOTE="BigTex, post: 224395, member: 43589"] The problem with using any GHRH (sermorelin) even the stronger analogs as a stand alone is that they are only highly effective when somatostatin is low. Remember somatostatin is the GH inhibitory hormone. So if you unluckily administer in a trough (somatostatin is high) you will add very little GH release. If you luckily enough to administer during a rising wave or GH pulse when somatostatin is low you will add to GH release. This true no matter what analog of GHRH you use, which is why you need to add a GHRP. The GHRP (eg. Ipamorelin) reduces somatostatin making the Sermorelin much more effective as it increases GH pulse. Further the lack of somatostatin will cause a positive effect on the pituitary further increasing you natural level of GHRH with further increases you natural pulse of GH. So the two have a very synergistic effect on the actions of each peptide. By using Ipamorelin with Sermorelin you greatly increase the body's natural GH pulse by lowering somatostatin. GH has the ability to stimulate lipolysis or the release of fat stores the more GH you produce the more you stimulate lipolysis. This same effect will happen using GHRP 2, GHRP 6 or even Hexarelin. [/QUOTE]
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Sermorelin
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