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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Relationship Between Higher PSA and Higher SHBG
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<blockquote data-quote="Cataceous" data-source="post: 227166" data-attributes="member: 38109"><p>Correction: If your SHBG were 30 instead of 50 <em><strong>and</strong></em> you demanded total testosterone remain unchanged then free testosterone would have to be increased to make this happen. But the reality is that your body regulates for its preferred level of free testosterone, so there's no pressure to increase it; if you simply remove 20 nMol/L of your SHBG then your free testosterone doesn't change and total testosterone drops by the amount that was bound to the SHBG you removed.</p><p></p><p>This explanation is slightly simplified. The nitty-gritty is that reducing SHBG affects the equilibrium with free testosterone. This means that total testosterone ends up a little different than if you only subtract the amount that was bound to the removed SHBG.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 227166, member: 38109"] Correction: If your SHBG were 30 instead of 50 [I][B]and[/B][/I] you demanded total testosterone remain unchanged then free testosterone would have to be increased to make this happen. But the reality is that your body regulates for its preferred level of free testosterone, so there's no pressure to increase it; if you simply remove 20 nMol/L of your SHBG then your free testosterone doesn't change and total testosterone drops by the amount that was bound to the SHBG you removed. This explanation is slightly simplified. The nitty-gritty is that reducing SHBG affects the equilibrium with free testosterone. This means that total testosterone ends up a little different than if you only subtract the amount that was bound to the removed SHBG. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Relationship Between Higher PSA and Higher SHBG
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