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Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
PSA numbers increasing on testosterone- Should I stop TRT?
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<blockquote data-quote="Nelson Vergel" data-source="post: 216873" data-attributes="member: 3"><p>Everyone with baseline low T has a slight increase in PSA when starting TRT. It's part of the saturation point.</p><p></p><h2>Time-course of effects on the prostate</h2><p>In hypogonadal men treated with testosterone, levels of PSA rise usually up to levels of eugonadal men <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib84" target="_blank">(84)</a>. Upon judging the time-course of effects of testosterone on the prostate, it is of note that aging itself is a factor in the rise of both prostate volume and PSA <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib84" target="_blank">(84)</a>, and there is no endpoint in the effects of testosterone on the prostate. A rise in PSA levels was noticed after 6 months, whereafter over the following 24 months there was no significant further increase <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib85" target="_blank">(85)</a>. Other studies have found a rise of PSA levels after 3 months <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib40" target="_blank">(40)</a>, some only after 12 months <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib43" target="_blank">(43)</a>. An increase in prostate volume was noted after 3 months <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib86" target="_blank">(86)</a> and after 12 months <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib44" target="_blank">(44)</a>. One study over 24 months found no significant increase in both PSA and prostate volume. In a study of 123 subjects over 42 months of testosterone gel application, there was significant increase in serum PSA over the first 6 months and then no further significant increases with continued testosterone treatment was found <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib87" target="_blank">(87)</a>. In a study of 81 hypogonadal men (mean age 56.8 years) followed for a mean (range) of 33.8 (6–144) months PSA levels did not increase significantly at 1-year intervals for 5 years <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib88" target="_blank">(88)</a>. The data are summarized in <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/figure/fig5/" target="_blank">Fig. 5</a>.</p><p></p><p>[ATTACH=full]19611[/ATTACH]</p><p></p><p>Reference: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/" target="_blank">Onset of effects of testosterone treatment and time span until maximum effects are achieved</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 216873, member: 3"] Everyone with baseline low T has a slight increase in PSA when starting TRT. It's part of the saturation point. [HEADING=1]Time-course of effects on the prostate[/HEADING] In hypogonadal men treated with testosterone, levels of PSA rise usually up to levels of eugonadal men [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib84'](84)[/URL]. Upon judging the time-course of effects of testosterone on the prostate, it is of note that aging itself is a factor in the rise of both prostate volume and PSA [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib84'](84)[/URL], and there is no endpoint in the effects of testosterone on the prostate. A rise in PSA levels was noticed after 6 months, whereafter over the following 24 months there was no significant further increase [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib85'](85)[/URL]. Other studies have found a rise of PSA levels after 3 months [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib40'](40)[/URL], some only after 12 months [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib43'](43)[/URL]. An increase in prostate volume was noted after 3 months [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib86'](86)[/URL] and after 12 months [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib44'](44)[/URL]. One study over 24 months found no significant increase in both PSA and prostate volume. In a study of 123 subjects over 42 months of testosterone gel application, there was significant increase in serum PSA over the first 6 months and then no further significant increases with continued testosterone treatment was found [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib87'](87)[/URL]. In a study of 81 hypogonadal men (mean age 56.8 years) followed for a mean (range) of 33.8 (6–144) months PSA levels did not increase significantly at 1-year intervals for 5 years [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/#bib88'](88)[/URL]. The data are summarized in [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/figure/fig5/']Fig. 5[/URL]. [ATTACH type="full"]19611[/ATTACH] Reference: [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/"]Onset of effects of testosterone treatment and time span until maximum effects are achieved[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
PSA numbers increasing on testosterone- Should I stop TRT?
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