Protocol advice to increase E2

[Azza23]

Hi all,

Ive been on TRT for about 2 years now and dont seem to be able to find my optimal protocol.

I am currently on enantate E4D at 120mg.

My Free T is 677 pmol/L (225-725)
SHBG 22 nmol/L (10-70)
E2 21.25 pg/mL

Mentally I dont feel like I should be where I need to be, tired, anxious, jealous. Just feeling horrible and seem to be getting injured all the time and taking forever to heal.

One thing I would like to try to EOD to see if that could boost my E2. I have heard that EOD injections with a lowish SHBG can help increase E2.

It would 56mg EOD.

Thoughts?

 

[Vince]

56mg of T too high a dose. I would try 30 mg of T eod along with 500 iu of hcg and 25 mg of dhea.

 

[Azza23]

Hi Vince,

Appreciate the reply.

Applogies but it is actually 48mg EOD.

What is the benefit of HCG? Will that reactivate my testes so I can have kids, something myself and my partner are considering. Will that also bump up my E2?

Unfortunately DHEA is illegal in Australia unless prescribed.

Thanks again

 

[Vince]

HCG increase E2 by its direct stimulation of aromatization in Leydig cells.

 

[Azza23]

HCG increase E2 by its direct stimulation of aromatization in Leydig cells.

I think that's what I could be missing to get my e2 higher.

If I am injecting 48mg of Test E EOD, what should my protocol be for HCG?

Also, what is everyone’s preferences for syringe sizes? Currently using 25g

 

[Vince]

I use an easy touch 29G half inch syringe. For both hCG and testosterone cypionate in grape seed oil.

You could try anywhere from 250 iu to 500 iu twice a week.

 

[Azza23]

I use an easy touch 29G half inch syringe. For both hCG and testosterone cypionate in grape seed oil.

You could try anywhere from 250 iu to 500 iu twice a week.

Thanks mate.

Do you IM or Sub?

 

[Vince]

Thanks mate.

Do you IM or Sub?

Shallow IM, shoulders and VG

Best testosterone injection site, no aspiration needed, avoids all nerves

So I ran across the term "Ventrogluteal IM injection site" and found an article describing it as what is currently the most medically recommended injection site. I tried it a few times now and have to agree. No blood gushing pinholes, no veins, no nerves, minimal pain. IN: The Ventrogluteal IM...

www.excelmale.com

 

[Azza23]

Shallow IM, shoulders and VG

Best testosterone injection site, no aspiration needed, avoids all nerves

So I ran across the term "Ventrogluteal IM injection site" and found an article describing it as what is currently the most medically recommended injection site. I tried it a few times now and have to agree. No blood gushing pinholes, no veins, no nerves, minimal pain. IN: The Ventrogluteal IM...

www.excelmale.com

Thanks mate

 

[Azza23]

Shallow IM, shoulders and VG

Best testosterone injection site, no aspiration needed, avoids all nerves

So I ran across the term "Ventrogluteal IM injection site" and found an article describing it as what is currently the most medically recommended injection site. I tried it a few times now and have to agree. No blood gushing pinholes, no veins, no nerves, minimal pain. IN: The Ventrogluteal IM...

www.excelmale.com

Thanks again.

Moving forward, Im going to go with 40mg of T and 300 of HCG EOD

 

[Azza23]

Shallow IM, shoulders and VG

Best testosterone injection site, no aspiration needed, avoids all nerves

So I ran across the term "Ventrogluteal IM injection site" and found an article describing it as what is currently the most medically recommended injection site. I tried it a few times now and have to agree. No blood gushing pinholes, no veins, no nerves, minimal pain. IN: The Ventrogluteal IM...

www.excelmale.com

Im three weeks into lowering my dose of enanthate from 120mg E4D to 48mg EOD…to say it’s been hell, would be an understatement. Would it be ok to lower it again slightly (let’s say 40mg or 44mg EOD) now or would it best to wait until the end of week 8 before making any changes?

 

[Vince]

Im three weeks into lowering my dose of enanthate from 120mg E4D to 48mg EOD…to say it’s been hell, would be an understatement. Would it be ok to lower it again slightly (let’s say 40mg or 44mg EOD) now or would it best to wait until the end of week 8 before making any changes?

40 MG every other day is still a high dose. It definitely won’t hurt you to lower it.

 

[Azza23]

40 MG every other day is still a high dose. It definitely won’t hurt you to lower it.

Id like to get down to 30mg EOD, but should I do it now or wait until the end of the 8 weeks?

 

[Vince]

Id like to get down to 30mg EOD, but should I do it now or wait until the end of the 8 weeks?

I would just do it now.

 

[Azza23]

I would just do it now.

Straight to 30 or have three weeks at 40, then 3 at 36 then 30?

Just dont want to have any more sides than I have to

 

[Gunga]

Straight to 30 or have three weeks at 40, then 3 at 36 then 30?

Just dont want to have any more sides than I have to

I’m with Vince. 30-36 mgs eod makes sense. If you’re asking for an opinion you will not be hurt by starting lower. Worst case you move up a bit. Less likelihood of throwing other markers off. I don’t think you’ll need it. That’s still an extremely high dose relative to the population of TRT folks.

 

[Azza23]

I’m with Vince. 30-36 mgs eod makes sense. If you’re asking for an opinion you will not be hurt by starting lower. Worst case you move up a bit. Less likelihood of throwing other markers off. I don’t think you’ll need it. That’s still an extremely high dose relative to the population of TRT folks.

Thanks Gunga.

My next jab is tomorrow and Ill go for 36mg, then 30mg for next week. Therefore Im moving from 210mg (120mg E4D) a week to 168mg (48mg EOD) a week, to 126mg (36mg EOD) a week, to 105mg (30mg EOD) a week.

Just want to minimise my sides as much as possible.