madman
Super Moderator
Conclusions
A rigorous biochemical diagnosis of adult growth hormone deficiency is required to distinguish pathologically attenuated growth hormone levels from diminished levels due to normal aging. Growth hormone replacement may be beneficial for persons with proven adult growth hormone deficiency, but randomized, controlled trials are needed to refine individualized efficacy markers and determine survival benefits. With respect to growth hormone for frail elderly patients with normal pituitary function, trials are needed to determine when and how the action of growth hormone on tissue undergoes a programmed switch from beneficial effects in younger persons to detrimental effects for longevity in older persons.
A rigorous biochemical diagnosis of adult growth hormone deficiency is required to distinguish pathologically attenuated growth hormone levels from diminished levels due to normal aging. Growth hormone replacement may be beneficial for persons with proven adult growth hormone deficiency, but randomized, controlled trials are needed to refine individualized efficacy markers and determine survival benefits. With respect to growth hormone for frail elderly patients with normal pituitary function, trials are needed to determine when and how the action of growth hormone on tissue undergoes a programmed switch from beneficial effects in younger persons to detrimental effects for longevity in older persons.
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