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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Need some help with dosing Progesterone. Did I over shoot the mark?
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<blockquote data-quote="Cataceous" data-source="post: 237793" data-attributes="member: 38109"><p>There's still a lack of standardization in hormone testing, so you should be cautious when comparing your progesterone measurements to other ranges. If your lab did things properly then its range should reflect their results from a normal population. We have the same issue here, with two of the major labs, Labcorp and Quest, having very different ranges for progesterone, 0.0-0.5 ng/mL and <= 1.4 ng/mL respectively.</p><p></p><p>My conclusion is that in the absence of additional information you have to rely on the lab's reference range. This makes it questionable for you to be tinkering with progesterone, but you probably won't get into too much trouble with short-term experimenting. My guess is that you experienced a honeymoon effect with that first dose. In TRT guys may spend years trying fruitlessly to recreate the great boost they got when just starting. Don't fall into that trap. With hormones, a fair evaluation of a new protocol requires that you wait weeks for things to settle down.</p><p></p><p>Regardless of the details, it's highly likely that 22 mg per day of topical progesterone is putting your serum levels above what's physiological. You definitely need to get new lab work to see where you stand. If you're suspicious of the progesterone reference range of your current lab then perhaps you can try a different lab. Or maybe this lab also offers a different assay. Typically the lowest cost test is based on an immunoassay, but there are also tests based on mass spectrometry.</p><p></p><p>I do think progesterone can be a useful addition to a TRT protocol, but the overall benefits may be subtle, and it's wise to keep things balanced and physiological.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 237793, member: 38109"] There's still a lack of standardization in hormone testing, so you should be cautious when comparing your progesterone measurements to other ranges. If your lab did things properly then its range should reflect their results from a normal population. We have the same issue here, with two of the major labs, Labcorp and Quest, having very different ranges for progesterone, 0.0-0.5 ng/mL and <= 1.4 ng/mL respectively. My conclusion is that in the absence of additional information you have to rely on the lab's reference range. This makes it questionable for you to be tinkering with progesterone, but you probably won't get into too much trouble with short-term experimenting. My guess is that you experienced a honeymoon effect with that first dose. In TRT guys may spend years trying fruitlessly to recreate the great boost they got when just starting. Don't fall into that trap. With hormones, a fair evaluation of a new protocol requires that you wait weeks for things to settle down. Regardless of the details, it's highly likely that 22 mg per day of topical progesterone is putting your serum levels above what's physiological. You definitely need to get new lab work to see where you stand. If you're suspicious of the progesterone reference range of your current lab then perhaps you can try a different lab. Or maybe this lab also offers a different assay. Typically the lowest cost test is based on an immunoassay, but there are also tests based on mass spectrometry. I do think progesterone can be a useful addition to a TRT protocol, but the overall benefits may be subtle, and it's wise to keep things balanced and physiological. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Need some help with dosing Progesterone. Did I over shoot the mark?
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