I'm thinking it won't make a significant difference for most men once you're "dialed in". I moved to subq because it was easier and no risk of scaring muscle tissue. Also, I'm in an area where there's no legal, free method to dispose of sharps, so using insulin syringes for subq shots means I can snip the tips off the syringes, throw away the rest of the syringe, and then throw away the snipper once it's full. Make it easy all the way around for me.
I expect these claims would not hold up under controlled conditions, at least if we're talking about areas under the curves. Single serum measurements can of course be quite different due to the different absorption rates/apparent half-lives.
Honsestly IM and SubQ are equally easy for me.... I use a 27g 1 1/2" needle for my IM injects in the Buttox and you can't even feel it going in and literally takes me the same amount of time to inject as SubQ... For SubQ I use 27g 1/2" insulin needle alternating left/right buttox.... as I posted earlier, my Testosterone levels were higher and more steady on SubQ as it was just the jump in E2 that pushed me back to IM.... I've been over 10yrs on TRT doing IM and never have gotten dialed in... time to switch it up.. Especially because of my single digit low SHBG I'm thinking eod SubQ would be the way to go right now... Looking at going to test Cyp 160mg total 3xWK - Monday 50mg, Wed 50mg and Fri 60mg (to account for the xtra day)
Not sure if you finally got dialed in but I had a similar problem with low shbg & struggled for years to figure trt out. Most doctors have no idea how to manage low shbg guys. I think your dose at 120 per week Everyday subQ was still too high, that’s why your E2 was so elevated. Forget about total T & just focus on keeping your free t from going toI high. That’s what matters. You may find that 80-100mg per week is all you need without needing an AI. I went to 12mg everyday SubQ & feel incredible, free T upper 1/3, no AI, E2 mid range. I notice if I go up to 14mg per day I don’t feel as good. As a matter of fact I may experiment going lower. The best advice I ever got was from a very well known trt doctor who told me to manage my dose 100% by how you feel. That’s how you dial in. I recommend keeping a daily Log of dose & how you feel. Remember, the max testosterone your body produces naturally when your young is only 4-7mg per day. Testosterone cypionate is 70% test, 30% oil. If you dose Just 10mg of cyp per day you’re netting 7mg which is the max the male body produces. Less is more. The US docs have guys way to over prescribed, that’s why they’re all on here trying to figure out a protocol.
Good advice there about physiological dosing, but this statement may be confusing. Testosterone cypionate is 70% testosterone and 30% cypionate ester. The ester is distinct from the carrier oil, and is not usually called "oil." In a conventional 200 mg/mL testosterone cypionate product each milliliter has 140 mg testosterone, 60 mg cypionate ester and a small amount of preservative. The balance, 70-80%, is the carrier oil, e.g. grape seed oil.
