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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Monthly Variations in Testosterone Levels: Results from 8,367 Middle-Aged Men
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<blockquote data-quote="Nelson Vergel" data-source="post: 193504" data-attributes="member: 3"><p><strong>Variation in levels of serum testosterone in monthly samples from healthy men</strong></p><p>Eur Urol Open Sci 2020;19(Suppl 2):e130</p><p></p><p>Lee J.H.</p><p></p><p>National Police Hospital, Dept. of Urology, Seoul, South Korea</p><p></p><p><strong>Introduction & Objectives: </strong>It is well known that testosterone deficiency syndrome is related to increased insulin resistance, increased visceral fat, and erectile dysfunction. Therefore, the testosterone level is an important issue of men`s health. Daily fluctuations in testosterone have been reported in many articles. However, there has been little evidence concerning monthly fluctuations in testosterone and their results are inconsistent</p><p>across studies.</p><p></p><p>In this study, we investigated the aforementioned issues.</p><p></p><p>Materials & Methods: We enrolled a total of 9,318 middle-aged men who had received health check-ups from 2011 to 2013. We excluded participants who had taken 5 alpha-reductase inhibitors or anti-psychotics, received androgen replacement therapy, and diagnosed with any kind of cancer. Serum testosterone was measured via radioimmunoassay and serum was collected between 7:00 and 9:00 AM. Analyses were conducted with the R statistical package.</p><p></p><p><strong>Results:</strong> Mean age, BMI, and testosterone were 50.6±5.5 years old, 25.1±2.7kg/m2, and 5.2±1.6ng/mL, respectively. And 37.4% of participants had metabolic syndrome. The trough testosterone level was observed in May (4.46ng/mL) and the peak level was observed in Jan (5.94ng/mL). The relative difference ((peak – trough)/peak) was 24.9% and absolute difference (peak - trough) was 1.48ng/mL. The ratio of testosterone <3.5ng/mL was highest in May (23.4%) and lowest in Jan (3.0%) (P<.001). After adjusting age, BMI, and the number of metabolic syndromes, the trough testosterone level was also observed in May and the peak level in Jan. (adjusted mean (95% CI)ng/mL; May, 4.390(4.239-4.542); Jan., 5.968(5.832-6.104))</p><p></p><p><strong>Conclusions: </strong>We found that monthly variation in levels of testosterone. In the diagnosis of testosterone deficiency, careful consideration of monthly variation in levels of testosterone would be needed. Further investigational studies would be needed to confirm our data.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 193504, member: 3"] [B]Variation in levels of serum testosterone in monthly samples from healthy men[/B] Eur Urol Open Sci 2020;19(Suppl 2):e130 Lee J.H. National Police Hospital, Dept. of Urology, Seoul, South Korea [B]Introduction & Objectives: [/B]It is well known that testosterone deficiency syndrome is related to increased insulin resistance, increased visceral fat, and erectile dysfunction. Therefore, the testosterone level is an important issue of men`s health. Daily fluctuations in testosterone have been reported in many articles. However, there has been little evidence concerning monthly fluctuations in testosterone and their results are inconsistent across studies. In this study, we investigated the aforementioned issues. Materials & Methods: We enrolled a total of 9,318 middle-aged men who had received health check-ups from 2011 to 2013. We excluded participants who had taken 5 alpha-reductase inhibitors or anti-psychotics, received androgen replacement therapy, and diagnosed with any kind of cancer. Serum testosterone was measured via radioimmunoassay and serum was collected between 7:00 and 9:00 AM. Analyses were conducted with the R statistical package. [B]Results:[/B] Mean age, BMI, and testosterone were 50.6±5.5 years old, 25.1±2.7kg/m2, and 5.2±1.6ng/mL, respectively. And 37.4% of participants had metabolic syndrome. The trough testosterone level was observed in May (4.46ng/mL) and the peak level was observed in Jan (5.94ng/mL). The relative difference ((peak – trough)/peak) was 24.9% and absolute difference (peak - trough) was 1.48ng/mL. The ratio of testosterone <3.5ng/mL was highest in May (23.4%) and lowest in Jan (3.0%) (P<.001). After adjusting age, BMI, and the number of metabolic syndromes, the trough testosterone level was also observed in May and the peak level in Jan. (adjusted mean (95% CI)ng/mL; May, 4.390(4.239-4.542); Jan., 5.968(5.832-6.104)) [B]Conclusions: [/B]We found that monthly variation in levels of testosterone. In the diagnosis of testosterone deficiency, careful consideration of monthly variation in levels of testosterone would be needed. Further investigational studies would be needed to confirm our data. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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Monthly Variations in Testosterone Levels: Results from 8,367 Middle-Aged Men
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