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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Microdosing Enanthate
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<blockquote data-quote="tareload" data-source="post: 214761"><p>Amen!</p><p></p><p></p><p></p><p>You mean his SHBG will have a significant impact on his TT (not fT)?</p><p></p><p>I know we go back and forth trying to explain this to guys but might as well try to make sure folks don't keep repeating the same flawed arguments.</p><p></p><p>[URL unfurl="true"]https://forums.t-nation.com/t/800mg-test-cyp-a-week-total-test-is-only-1406/275359/85[/URL]</p><p></p><p>Pasted from above link:</p><p></p><p>SHBG is related (correlated) to but doesn’t appear to drive (causation) clearance rate. There’s a whole bunch of stuff that determines how your body clears fT, SHBG is not one of them. Your body eliminates based on free T not Total T. TT is set by your SHBG and free T via dynamic equilibrium (chemical kinetics). Guys typically look at their TT and get confused as hell when trying to understand clearance rate. This is where this idea that guys who have lower SHBG need to inject more frequently came from. For the same fT a low SHBG guy will read a lower TT so he thinks he isn’t getting the same bang for his buck even though his fT is the same as the higher SHBG guy. In addition, I’ll argue that WE don’t understand the value of keeping supra T (TT and fT) levels constant with respect to positive vs negative side effects.</p><p></p><p>Hence, for 250 mg/week of TC (mild cycle for many based on their metabolic clearance rate of free T), do we need to inject ED or once weekly if our SHBG is 10?</p><p></p><p>Remember, elimination is driven by free T not Total T. If you really want to know your elimination kinetics it will take some work as I’ve discussed a few times how you can measure AUC and determine how your body processes T. Still seems trial and error to me and related to age, liver activity, lymphatic activity, where you inject, blah blah.</p><p></p><p>Example:</p><p>So what’s the goal? Gainz or something else?</p><p>Given SHBG of 10.</p><p>Given 250 mg/week of TC.</p><p></p><p>Better to inject every day and keep constant TT (constant free T) at say 1500 ng/dL (55 ng/dL) or inject once weekly and have peak TT (fT) at 2000 ng/dL (77 ng/dL) and trough TT (fT) at 1000 ng/dL (36 nd/dL)?</p><p></p><p>Good question that I can’t answer for an individual. Running your body at constant and HIGH TT(fT) levels continuously seems like a bad idea from health perspective. From GAINZ perspective, I have no clue. <em>What drives GAINZ, fT or TT and what’s their individual contributions? No one knows as far as I can tell. Others thoughts or feedback?</em></p><p></p><p>Homework: do this same example for a guy with an SHBG of 30 nmol/L and <a href="http://www.issam.ch/freetesto.htm" target="_blank">compute</a> the TT / fT levels for ED vs weekly injections? What does this tell you?</p><p></p><p>And of course the obligatory credit where credit is due:</p><p>[URL unfurl="true"]https://forums.t-nation.com/t/800mg-test-cyp-a-week-total-test-is-only-1406/275359/95[/URL]</p></blockquote><p></p>
[QUOTE="tareload, post: 214761"] Amen! You mean his SHBG will have a significant impact on his TT (not fT)? I know we go back and forth trying to explain this to guys but might as well try to make sure folks don't keep repeating the same flawed arguments. [URL unfurl="true"]https://forums.t-nation.com/t/800mg-test-cyp-a-week-total-test-is-only-1406/275359/85[/URL] Pasted from above link: SHBG is related (correlated) to but doesn’t appear to drive (causation) clearance rate. There’s a whole bunch of stuff that determines how your body clears fT, SHBG is not one of them. Your body eliminates based on free T not Total T. TT is set by your SHBG and free T via dynamic equilibrium (chemical kinetics). Guys typically look at their TT and get confused as hell when trying to understand clearance rate. This is where this idea that guys who have lower SHBG need to inject more frequently came from. For the same fT a low SHBG guy will read a lower TT so he thinks he isn’t getting the same bang for his buck even though his fT is the same as the higher SHBG guy. In addition, I’ll argue that WE don’t understand the value of keeping supra T (TT and fT) levels constant with respect to positive vs negative side effects. Hence, for 250 mg/week of TC (mild cycle for many based on their metabolic clearance rate of free T), do we need to inject ED or once weekly if our SHBG is 10? Remember, elimination is driven by free T not Total T. If you really want to know your elimination kinetics it will take some work as I’ve discussed a few times how you can measure AUC and determine how your body processes T. Still seems trial and error to me and related to age, liver activity, lymphatic activity, where you inject, blah blah. Example: So what’s the goal? Gainz or something else? Given SHBG of 10. Given 250 mg/week of TC. Better to inject every day and keep constant TT (constant free T) at say 1500 ng/dL (55 ng/dL) or inject once weekly and have peak TT (fT) at 2000 ng/dL (77 ng/dL) and trough TT (fT) at 1000 ng/dL (36 nd/dL)? Good question that I can’t answer for an individual. Running your body at constant and HIGH TT(fT) levels continuously seems like a bad idea from health perspective. From GAINZ perspective, I have no clue. [I]What drives GAINZ, fT or TT and what’s their individual contributions? No one knows as far as I can tell. Others thoughts or feedback?[/I] Homework: do this same example for a guy with an SHBG of 30 nmol/L and [URL='http://www.issam.ch/freetesto.htm']compute[/URL] the TT / fT levels for ED vs weekly injections? What does this tell you? And of course the obligatory credit where credit is due: [URL unfurl="true"]https://forums.t-nation.com/t/800mg-test-cyp-a-week-total-test-is-only-1406/275359/95[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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Microdosing Enanthate
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