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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Metformin as an Aromatase Inhibitor?
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<blockquote data-quote="jaimeruiz99" data-source="post: 200473" data-attributes="member: 17672"><p>Well, yes. </p><p></p><p>Hyperinsulinemia is a factor in excessive aromatization. The production of insulin stimulates aromatase. Metformin reduces insulin, thereby curbing the activity of aromatase via the aforementioned downstream mechanism.</p><p></p><p>Do note that I am not advocating the use of Metformin as an aromatase inhibitor in cases where estradiol is significantly above threshold values, such as cases where someone is running a cycle dose.</p><p></p><p>Where I find it's value is in cases of men running reasonable doses of testosterone per week, who appear to have issues getting testosterone to within range but are not significantly above threshold values. These men would be better served running a small dose of Metformin per day, which will allow estradiol to dip just below the threshold and stay within range.</p><p></p><p>For example: we have person running 100 mg of testosterone per week but their estradiol is 10 or perhaps 20 points above the laboratory limit. Not all that high, but producing very minor symptoms regardless (water retention and slight emotionality). Rather than using an AI, they can utilize Metformin, which can bring their levels to within range or just slightly above it, with absolutely no risk of crashing their estradiol or having to deal with compounding microdoses of Arimidex.</p><p></p><p>In cases where the same person has an estradiol double the laboratory limit however, then yes, it might be argued that Arimidex is a better solution.</p></blockquote><p></p>
[QUOTE="jaimeruiz99, post: 200473, member: 17672"] Well, yes. Hyperinsulinemia is a factor in excessive aromatization. The production of insulin stimulates aromatase. Metformin reduces insulin, thereby curbing the activity of aromatase via the aforementioned downstream mechanism. Do note that I am not advocating the use of Metformin as an aromatase inhibitor in cases where estradiol is significantly above threshold values, such as cases where someone is running a cycle dose. Where I find it's value is in cases of men running reasonable doses of testosterone per week, who appear to have issues getting testosterone to within range but are not significantly above threshold values. These men would be better served running a small dose of Metformin per day, which will allow estradiol to dip just below the threshold and stay within range. For example: we have person running 100 mg of testosterone per week but their estradiol is 10 or perhaps 20 points above the laboratory limit. Not all that high, but producing very minor symptoms regardless (water retention and slight emotionality). Rather than using an AI, they can utilize Metformin, which can bring their levels to within range or just slightly above it, with absolutely no risk of crashing their estradiol or having to deal with compounding microdoses of Arimidex. In cases where the same person has an estradiol double the laboratory limit however, then yes, it might be argued that Arimidex is a better solution. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Metformin as an Aromatase Inhibitor?
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