ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Low Testosterone in Men: Recommendations on the diagnosis, treatment and monitoring
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 206872" data-attributes="member: 13851"><p><strong><u>AR CAG repeat lengths</u> (short/long)</strong></p><p></p><p><em><strong>*The number of cytosine–adenine–guanine triplet (CAG) repeats in androgen receptors differ in men and influences the androgen receptor activity [88,89,90,91] (Figure 1). <u>Hence testosterone sensitivity may vary in different individuals</u>.</strong> </em></p><p><em></em></p><p><em><strong>*The same applies to <u>androgen receptor gene CAG repeat lengths >24 in the presence of symptoms and normal testosterone levels</u> may be considered as a state of preclinical TD [93]</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*In general, it is currently speculated that variable phenotypes of androgen insensitivity exist, mainly owing to mutated androgen receptors. <u>More subtle modulation of androgen effects is related to the CAG repeat polymorphism in exon 1 of the androgen receptor gene</u>: transcription of androgen-dependent target genes are attenuated with the increasing length of triplets. </strong></em></p><p><em><strong></strong></em></p><p><em><strong><u>*As a clinical entity, the CAG repeat polymorphism can relate to variations of androgenicity in men in various tissues and psychological traits</u>: The longer the CAG repeat polymorphism, the less prominent is the androgen effect when individuals with similar testosterone concentrations are compared. </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<u>A strictly defined threshold to TD is likely to be replaced by a continuum spanned by genetics as well as symptom specificity</u>. In addition, the effects of externally applied testosterone can be markedly influenced by the CAG repeats and respective pharmacogenetic implications are likely to influence indications as well as modalities of testosterone treatment of hypogonadal men. Investigation of CAG repeat polymorphism in exon 1 of the androgen receptor gene may be useful in testosterone treatment regimens adjustment</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 206872, member: 13851"] [B][U]AR CAG repeat lengths[/U] (short/long)[/B] [I][B]*The number of cytosine–adenine–guanine triplet (CAG) repeats in androgen receptors differ in men and influences the androgen receptor activity [88,89,90,91] (Figure 1). [U]Hence testosterone sensitivity may vary in different individuals[/U].[/B] [B]*The same applies to [U]androgen receptor gene CAG repeat lengths >24 in the presence of symptoms and normal testosterone levels[/U] may be considered as a state of preclinical TD [93] *In general, it is currently speculated that variable phenotypes of androgen insensitivity exist, mainly owing to mutated androgen receptors. [U]More subtle modulation of androgen effects is related to the CAG repeat polymorphism in exon 1 of the androgen receptor gene[/U]: transcription of androgen-dependent target genes are attenuated with the increasing length of triplets. [U]*As a clinical entity, the CAG repeat polymorphism can relate to variations of androgenicity in men in various tissues and psychological traits[/U]: The longer the CAG repeat polymorphism, the less prominent is the androgen effect when individuals with similar testosterone concentrations are compared. *[U]A strictly defined threshold to TD is likely to be replaced by a continuum spanned by genetics as well as symptom specificity[/U]. In addition, the effects of externally applied testosterone can be markedly influenced by the CAG repeats and respective pharmacogenetic implications are likely to influence indications as well as modalities of testosterone treatment of hypogonadal men. Investigation of CAG repeat polymorphism in exon 1 of the androgen receptor gene may be useful in testosterone treatment regimens adjustment[/B][/I] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Low Testosterone in Men: Recommendations on the diagnosis, treatment and monitoring
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top