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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Low free t3 cardiovascular mortality
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<blockquote data-quote="dnfuss" data-source="post: 122849" data-attributes="member: 15487"><p>This is a classic case of researchers presenting statistics so as to seem to assign them a relevance they simply do not merit. This was a meta-analysis. It is well-known that there is a tremendous risk of researcher bias in such analyses (they get to choose which studies are included and which aren't). And the studies analyzed were all surveys, which simply demonstrate correlation, not controlled trials. It has no value whatsoever in terms of any treatment regimen. It is, at best, an indication of possible future clinical trials.</p><p></p><p>And it avoids addressing the question of why there is no statistically significant association with all-cause mortality. To state it simply, even this very weak agglomeration of selected inconclusive associational surveys found no indication that those with the lowest t3 levels die even one day sooner than those with higher levels. None whatsoever.</p><p></p><p>Cardiovascular mortality is a subjective diagnosis. Many doctors indicate it as a cause of death as their default position if no other cause is overwhelmingly obvious. It cannot be accepted with absolute certainty without an autopsy, which is rarely done. Death by any cause is not subject to interpretation and is an extremely reliable end-point in analysis.</p><p></p><p>And even if the association with cardiovascular mortality is statistically significant (i.e., not simply due to chance), and I doubt it really is for the reasons stated above, that still doesn't imply that increasing a low free t3 level with drugs would reduce the risk of fatal cardiovascular events in those taking them, because correlation does not establish causation (i.e., there may be other reasons that those with low free t3 levels have more fatal heart attacks, if that is even true; maybe they also have higher blood sugars, blood pressures, or some other causative factor). Clinical double-blind placebo-controlled studies would be required to establish that.</p><p></p><p>I would not draw any conclusions from nor base any treatment decision on this study.</p></blockquote><p></p>
[QUOTE="dnfuss, post: 122849, member: 15487"] This is a classic case of researchers presenting statistics so as to seem to assign them a relevance they simply do not merit. This was a meta-analysis. It is well-known that there is a tremendous risk of researcher bias in such analyses (they get to choose which studies are included and which aren't). And the studies analyzed were all surveys, which simply demonstrate correlation, not controlled trials. It has no value whatsoever in terms of any treatment regimen. It is, at best, an indication of possible future clinical trials. And it avoids addressing the question of why there is no statistically significant association with all-cause mortality. To state it simply, even this very weak agglomeration of selected inconclusive associational surveys found no indication that those with the lowest t3 levels die even one day sooner than those with higher levels. None whatsoever. Cardiovascular mortality is a subjective diagnosis. Many doctors indicate it as a cause of death as their default position if no other cause is overwhelmingly obvious. It cannot be accepted with absolute certainty without an autopsy, which is rarely done. Death by any cause is not subject to interpretation and is an extremely reliable end-point in analysis. And even if the association with cardiovascular mortality is statistically significant (i.e., not simply due to chance), and I doubt it really is for the reasons stated above, that still doesn't imply that increasing a low free t3 level with drugs would reduce the risk of fatal cardiovascular events in those taking them, because correlation does not establish causation (i.e., there may be other reasons that those with low free t3 levels have more fatal heart attacks, if that is even true; maybe they also have higher blood sugars, blood pressures, or some other causative factor). Clinical double-blind placebo-controlled studies would be required to establish that. I would not draw any conclusions from nor base any treatment decision on this study. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Low free t3 cardiovascular mortality
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