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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Increased SHBG and not testosterone or estradiol is associated with bone loss and fractures
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<blockquote data-quote="DragonBits" data-source="post: 117584" data-attributes="member: 18023"><p>I was speculating that those with a higher SHBG level would be less affected by high estradiol levels.</p><p></p><p>But then I read the following research, which suggest that there maybe different SHBG variants. The SHBG that we measure mainly binds to testosterone while there may exist a variant of SHBG that binds with estradiol, and this variant is not being measured by any standard test.</p><p></p><p>Not only that, but the way estradiol behaving in morbidly obese men changes.</p><p></p><p><a href="http://www.eje-online.org/content/176/4/393.full" target="_blank">http://www.eje-online.org/content/176/4/393.full</a></p><p></p><p>In conclusion, our data point to SHBG as a globulin mainly centered in the control of testosterone levels, with estradiol regulation taking a markedly second place, or, simply, estradiol being controlled by a different SHBG variant. These data confirm the existence of different SHBG molecular species to discriminately bind estradiol and testosterone, previously reported in cirrhotic subjects (54). The sex-related differences in the relationships of binding vs levels of hormones and SHBG could not be explained by assuming that a single dimeric protein may experience the dramatic changes in affinity for testosterone and estradiol (differently for both, in fact) observed in women and men, and the marked differential effects of obesity on the ability of the same protein to bind testosterone and estradiol (Table 3).</p><p></p><p>Thus, we postulate that SHBG protein must be present in at least two different molecular species, or isoforms, to explain its differential function for both hormones, specially affected by sex and obesity. These conclusions suggest a much needed establishment of analytical procedures to identify these physiologically distinct forms of SHBG as the sole use of antibody-based measurements could not discriminate between them.</p></blockquote><p></p>
[QUOTE="DragonBits, post: 117584, member: 18023"] I was speculating that those with a higher SHBG level would be less affected by high estradiol levels. But then I read the following research, which suggest that there maybe different SHBG variants. The SHBG that we measure mainly binds to testosterone while there may exist a variant of SHBG that binds with estradiol, and this variant is not being measured by any standard test. Not only that, but the way estradiol behaving in morbidly obese men changes. [URL]http://www.eje-online.org/content/176/4/393.full[/URL] In conclusion, our data point to SHBG as a globulin mainly centered in the control of testosterone levels, with estradiol regulation taking a markedly second place, or, simply, estradiol being controlled by a different SHBG variant. These data confirm the existence of different SHBG molecular species to discriminately bind estradiol and testosterone, previously reported in cirrhotic subjects (54). The sex-related differences in the relationships of binding vs levels of hormones and SHBG could not be explained by assuming that a single dimeric protein may experience the dramatic changes in affinity for testosterone and estradiol (differently for both, in fact) observed in women and men, and the marked differential effects of obesity on the ability of the same protein to bind testosterone and estradiol (Table 3). Thus, we postulate that SHBG protein must be present in at least two different molecular species, or isoforms, to explain its differential function for both hormones, specially affected by sex and obesity. These conclusions suggest a much needed establishment of analytical procedures to identify these physiologically distinct forms of SHBG as the sole use of antibody-based measurements could not discriminate between them. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Increased SHBG and not testosterone or estradiol is associated with bone loss and fractures
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