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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
In search of Endocrinologist or thought leader concerning complex thyroid conditions.
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<blockquote data-quote="Cataceous" data-source="post: 149240" data-attributes="member: 38109"><p>If you're interested in an opposing view on the importance of reverse T3 results, here's a skeptical blog from ZRT: <a href="https://www.zrtlab.com/blog/archive/reverse-t3-why-its-not-useful-routine-thyroid-testing/" target="_blank">Reverse T3 – Why It’s Not Useful for Routine Thyroid Testing</a></p><p></p><p>... <em>Since high rT3 is linked with conditions associated with slow metabolism, it has been claimed in internet articles, but not in peer-reviewed papers, that rT3 causes a slowing in metabolism by blocking or obstructing the nuclear thyroid receptors. These receptors are the target sites where the primary active thyroid hormone, T3, binds, triggering its actions to drive cellular metabolism and maintain body temperature. Yet there is no credible scientific evidence that rT3 even enters the nucleus of the cell. While rT3 does not bind to, and has no known transcriptional activity at, the thyroid receptor, it does have potent non-genomic activity, mediated by binding to a specific thyroid receptor in the cytoplasm, as an initiator of actin polymerization in astrocytes in the brain <a href="https://www.zrtlab.com/blog/archive/reverse-t3-why-its-not-useful-routine-thyroid-testing/#edn_8" target="_blank">[8]</a><a href="https://www.zrtlab.com/blog/archive/reverse-t3-why-its-not-useful-routine-thyroid-testing/#edn_9" target="_blank">[9]</a>.</em> ...</p><p>...</p><p><em>There appears to be little clinical justification for routine testing of rT3 for thyroid function assessment <a href="https://www.zrtlab.com/blog/archive/reverse-t3-why-its-not-useful-routine-thyroid-testing/#edn_14" target="_blank">[14]</a>.</em> ...</p></blockquote><p></p>
[QUOTE="Cataceous, post: 149240, member: 38109"] If you're interested in an opposing view on the importance of reverse T3 results, here's a skeptical blog from ZRT: [URL='https://www.zrtlab.com/blog/archive/reverse-t3-why-its-not-useful-routine-thyroid-testing/']Reverse T3 – Why It’s Not Useful for Routine Thyroid Testing[/URL] ... [I]Since high rT3 is linked with conditions associated with slow metabolism, it has been claimed in internet articles, but not in peer-reviewed papers, that rT3 causes a slowing in metabolism by blocking or obstructing the nuclear thyroid receptors. These receptors are the target sites where the primary active thyroid hormone, T3, binds, triggering its actions to drive cellular metabolism and maintain body temperature. Yet there is no credible scientific evidence that rT3 even enters the nucleus of the cell. While rT3 does not bind to, and has no known transcriptional activity at, the thyroid receptor, it does have potent non-genomic activity, mediated by binding to a specific thyroid receptor in the cytoplasm, as an initiator of actin polymerization in astrocytes in the brain [URL='https://www.zrtlab.com/blog/archive/reverse-t3-why-its-not-useful-routine-thyroid-testing/#edn_8'][8][/URL][URL='https://www.zrtlab.com/blog/archive/reverse-t3-why-its-not-useful-routine-thyroid-testing/#edn_9'][9][/URL].[/I] ... ... [I]There appears to be little clinical justification for routine testing of rT3 for thyroid function assessment [URL='https://www.zrtlab.com/blog/archive/reverse-t3-why-its-not-useful-routine-thyroid-testing/#edn_14'][14][/URL].[/I] ... [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
In search of Endocrinologist or thought leader concerning complex thyroid conditions.
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