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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
How to Manage Post-SSRI Antidepressant Sexual Dysfunction (PSSD)
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<blockquote data-quote="Nelson Vergel" data-source="post: 210096" data-attributes="member: 3"><p>I did not know that this drug could be a possible treatment: Ganisetron (Kytril,) Injectable</p><p></p><p>Antiemetic</p><p>It can prevent nausea and vomiting caused by cancer treatments such as radiation and chemotherapy, including cisplatin. It can also treat and prevent nausea and vomiting after surgery.</p><p></p><p>It did not seem to work well in this study:</p><p></p><p><strong>A Placebo-Controlled, Crossover Trial of Granisetron in SRI-Induced Sexual Dysfunction</strong></p><p>July 2001The Journal of Clinical Psychiatry 62(6):469-73</p><p></p><p></p><p>Abstract</p><p>Sexual side effects are commonly associated with serotonin reuptake inhibitor (SRI) therapy. The mechanism underlying SRI-induced sexual dysfunction has been hypothesized to be mediated by direct serotonergic effects. Evidence from open-label reports suggests that cyproheptadine, nefazodone, mirtazapine, and mianserin, which block one or more serotonin receptors, may reverse sexual side effects. The current study was a prospective, randomized, crossover trial comparing granisetron, a serotonin-3 antagonist, with placebo in outpatients who developed sexual dysfunction during SRI treatment. Thirty-one outpatients who were currently experiencing sexual dysfunction associated with SRIs were randomly assigned to double-blind treatment with granisetron (1-1.5 mg) or placebo for use 1 to 2 hours prior to sexual activity. Patients rated sexual symptoms after each trial using the Sexual Side Effect Scale (SSES). After 4 trials of the medication, patients crossed over to the other treatment for 4 more trials. Twenty patients received at least 1 dose of placebo and granisetron. Analysis by repeated-measures analysis of variance showed no significant effects of granisetron relative to placebo. Significant improvement between baseline and treatment-phase SSES scores was observed for both granisetron (p = .0004) and placebo (p = .0081). The study medication was generally well tolerated. The results of this study do not support the efficacy of granisetron (1-2 mg) in the treatment of SRI-associated sexual side effects. A significant placebo response may be associated with the treatment of SRI-induced sexual dysfunction.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 210096, member: 3"] I did not know that this drug could be a possible treatment: Ganisetron (Kytril,) Injectable Antiemetic It can prevent nausea and vomiting caused by cancer treatments such as radiation and chemotherapy, including cisplatin. It can also treat and prevent nausea and vomiting after surgery. It did not seem to work well in this study: [B]A Placebo-Controlled, Crossover Trial of Granisetron in SRI-Induced Sexual Dysfunction[/B] July 2001The Journal of Clinical Psychiatry 62(6):469-73 Abstract Sexual side effects are commonly associated with serotonin reuptake inhibitor (SRI) therapy. The mechanism underlying SRI-induced sexual dysfunction has been hypothesized to be mediated by direct serotonergic effects. Evidence from open-label reports suggests that cyproheptadine, nefazodone, mirtazapine, and mianserin, which block one or more serotonin receptors, may reverse sexual side effects. The current study was a prospective, randomized, crossover trial comparing granisetron, a serotonin-3 antagonist, with placebo in outpatients who developed sexual dysfunction during SRI treatment. Thirty-one outpatients who were currently experiencing sexual dysfunction associated with SRIs were randomly assigned to double-blind treatment with granisetron (1-1.5 mg) or placebo for use 1 to 2 hours prior to sexual activity. Patients rated sexual symptoms after each trial using the Sexual Side Effect Scale (SSES). After 4 trials of the medication, patients crossed over to the other treatment for 4 more trials. Twenty patients received at least 1 dose of placebo and granisetron. Analysis by repeated-measures analysis of variance showed no significant effects of granisetron relative to placebo. Significant improvement between baseline and treatment-phase SSES scores was observed for both granisetron (p = .0004) and placebo (p = .0081). The study medication was generally well tolerated. The results of this study do not support the efficacy of granisetron (1-2 mg) in the treatment of SRI-associated sexual side effects. A significant placebo response may be associated with the treatment of SRI-induced sexual dysfunction. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
How to Manage Post-SSRI Antidepressant Sexual Dysfunction (PSSD)
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