How strict is Defy when it comes to elevated hematocrit/hemoglobin?


New Member
I’m new here so apologies if this is the wrong forum. I’m considering switching to Defy after 6 months on TRT at a local clinic. I’ve had elevated hemoglobin (high 17’s to low 18’s) and hematocrit (51-53%) most of the time I’ve been on TRT. But I was also on 180mg per week which is probably too much for me, so a month ago I dropped to 160mg. Blood donations help a bit but these numbers eventually creep back up. I’ve been drinking a gallon of water a day for a couple months now and it’s not helping much. Doing a sleep study soon to test for sleep apnea (my hemoglobin/hematocrit numbers were on the high end of the reference range before I started TRT).

My clinic isn’t too concerned with these numbers but Defy seems much more stringent; I believe in their initial paperwork it said they’ll pull you off TRT if your hematocrit goes above 51%. Is that true? If so, I’m wondering if this clinic will be a good fit for me. I’m concerned the only way I’ll get below 51% is by lowering my test dose so low I may as well not be on it. And I get a lot of conflicting info about the dangers of slightly elevated hematocrit/hemoglobin. Any insight into their management of these issues would be appreciated.


Active Member
Defy will not pull you off TRT for a 51 hct. 51 is actually high normal for some people. They might be concerned at 53 but even then there is no hard fast policy.


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