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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How can one increase SHBG when it is too low?
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<blockquote data-quote="Vestpocket" data-source="post: 17461" data-attributes="member: 4848"><p>Most of the studies related to increasing SHBG are pretty disappointing:</p><p></p><p>50 mcg of T3 will double it. However, this requires that you become hyperthyroid, and this was only shown with men who had normal SHBG to start. (25 mcg per day made me hyperthyroid (elevated T3 per lab range) but had zero effect on SHBG.))</p><p></p><p>Coffee will increase it by tiny percentage. Except, you have to be female, start with normal SHBG and drink enough that you get 400mg of caffeine, minimum.</p><p></p><p>Flax seed will boost it. The caveat is that you have to start with normal SHBG and that the only reason it increases is that lignans bind to and inactivate SHBG, so the body responds by making more since it is being taken out of use (if the body is able.) Essentially, it makes the blood test unreliable, because the test includes lignan bound SHBG.</p><p></p><p>Beyond thyroid, I've never seen a study that shows an adequate increase that would remedy a situation that either myself or ERO find ourselves in.</p><p></p><p>------------</p><p><strong>Sex hormone binding globulin deficiency due to a homozygous missense mutation.</strong></p><p><strong></strong></p><p><strong></strong>Vos MJ, Mijnhout GS, Rondeel JM, Baron W, Groeneveld PH</p><p>J Clin Endocrinol Metab. 2014 Jun 17:jc20142055</p><p></p><p>We identified a man with an undetectable SHBG concentration in combination with a low total testosterone. He presented with a seven-year history of muscle weakness, fatigue and a low libido. Objectives To determine the cause of the SHBG deficiency we both employed genetic analysis of the SHBG gene and transgene SHBG expression.</p><p>[...]</p><p>The female patient was asymptomatic, but the male patient presented with symptoms of <u>sexual dysfunction</u>, poor concentration, depressed mood and <u>muscle weakness</u>, raising the possibility of a <strong>role for a SHBG in some sex steroid actions (e.g. in brain and muscle).</strong></p></blockquote><p></p>
[QUOTE="Vestpocket, post: 17461, member: 4848"] Most of the studies related to increasing SHBG are pretty disappointing: 50 mcg of T3 will double it. However, this requires that you become hyperthyroid, and this was only shown with men who had normal SHBG to start. (25 mcg per day made me hyperthyroid (elevated T3 per lab range) but had zero effect on SHBG.)) Coffee will increase it by tiny percentage. Except, you have to be female, start with normal SHBG and drink enough that you get 400mg of caffeine, minimum. Flax seed will boost it. The caveat is that you have to start with normal SHBG and that the only reason it increases is that lignans bind to and inactivate SHBG, so the body responds by making more since it is being taken out of use (if the body is able.) Essentially, it makes the blood test unreliable, because the test includes lignan bound SHBG. Beyond thyroid, I've never seen a study that shows an adequate increase that would remedy a situation that either myself or ERO find ourselves in. ------------ [B]Sex hormone binding globulin deficiency due to a homozygous missense mutation. [/B]Vos MJ, Mijnhout GS, Rondeel JM, Baron W, Groeneveld PH J Clin Endocrinol Metab. 2014 Jun 17:jc20142055 We identified a man with an undetectable SHBG concentration in combination with a low total testosterone. He presented with a seven-year history of muscle weakness, fatigue and a low libido. Objectives To determine the cause of the SHBG deficiency we both employed genetic analysis of the SHBG gene and transgene SHBG expression. [...] The female patient was asymptomatic, but the male patient presented with symptoms of [U]sexual dysfunction[/U], poor concentration, depressed mood and [U]muscle weakness[/U], raising the possibility of a [B]role for a SHBG in some sex steroid actions (e.g. in brain and muscle).[/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How can one increase SHBG when it is too low?
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