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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
High estradiol even on anastrazole
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<blockquote data-quote="Cataceous" data-source="post: 200343" data-attributes="member: 38109"><p>Let's clarify the units for your testosterone. You should be discussing your dose of testosterone cypionate in terms of its weight in milligrams (mg). When you mention numbers like 0.5 and 1.0 you're presumably referring to the total volume injected in milliliters, which includes the carrier oil along with the testosterone. The problem is that testosterone cypionate concentrations can vary. Most common, at least in the U.S., is 200 mg per milliliter of volume. So 0.5 mL and 1.0 mL provide 100 and 200 mg of testosterone cypionate respectively, if this concentration applies to your product.</p><p></p><p>The dose of 100 mg per week is more reasonable by far than 200 mg. But when it's administered once weekly it has the potential to cause large swings in testosterone over the course of the week. A trough value of 700 ng/dL for total testosterone could mean you'd be pushing 2,000 ng/dL at peak. If the dose is divided into two injections a week then the difference between peaks and troughs is smaller. Typically peaks could be 50% higher than troughs with this pattern. Every other day dosing smooths out serum levels even more.</p><p></p><p>Regarding estradiol, there's nothing special about a T/E2 ratio of 30-1. I prefer to think about E2/T by weight. The 30-1 figure translates to about 0.3%, which I'd consider to be at the bottom of the normal aromatization range of 0.3-0.6%. Your value was a little under 0.6%, at the high end of normal, but nothing to fret about in the absence of symptoms.</p><p></p><p>The anecdotes I provided show than high T has the potential to create misery. Low estradiol can also cause some problems. In the other direction, higher estradiol is more likely to cause obvious misery when the aromatization rate is also high, meaning estradiol is relatively high compared to testosterone. This would not apply to your recent measurements, in which the aromatization rate is about 0.5%. However, estradiol over 70 pg/mL greatly exceeds what's expected in normal male physiology, so I don't recommend it either unless you're planning to be part of an experiment on the long-term safety of high levels.</p><p></p><p>My suggestion is that under Defy's supervision you cut back your testosterone cypionate dose to 70-90 mg cypionate split into at least two weekly doses with no AI. Give it some months to get through the transition. Only if your aromatization rate is high and you're having symptoms would I consider using the AI.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 200343, member: 38109"] Let's clarify the units for your testosterone. You should be discussing your dose of testosterone cypionate in terms of its weight in milligrams (mg). When you mention numbers like 0.5 and 1.0 you're presumably referring to the total volume injected in milliliters, which includes the carrier oil along with the testosterone. The problem is that testosterone cypionate concentrations can vary. Most common, at least in the U.S., is 200 mg per milliliter of volume. So 0.5 mL and 1.0 mL provide 100 and 200 mg of testosterone cypionate respectively, if this concentration applies to your product. The dose of 100 mg per week is more reasonable by far than 200 mg. But when it's administered once weekly it has the potential to cause large swings in testosterone over the course of the week. A trough value of 700 ng/dL for total testosterone could mean you'd be pushing 2,000 ng/dL at peak. If the dose is divided into two injections a week then the difference between peaks and troughs is smaller. Typically peaks could be 50% higher than troughs with this pattern. Every other day dosing smooths out serum levels even more. Regarding estradiol, there's nothing special about a T/E2 ratio of 30-1. I prefer to think about E2/T by weight. The 30-1 figure translates to about 0.3%, which I'd consider to be at the bottom of the normal aromatization range of 0.3-0.6%. Your value was a little under 0.6%, at the high end of normal, but nothing to fret about in the absence of symptoms. The anecdotes I provided show than high T has the potential to create misery. Low estradiol can also cause some problems. In the other direction, higher estradiol is more likely to cause obvious misery when the aromatization rate is also high, meaning estradiol is relatively high compared to testosterone. This would not apply to your recent measurements, in which the aromatization rate is about 0.5%. However, estradiol over 70 pg/mL greatly exceeds what's expected in normal male physiology, so I don't recommend it either unless you're planning to be part of an experiment on the long-term safety of high levels. My suggestion is that under Defy's supervision you cut back your testosterone cypionate dose to 70-90 mg cypionate split into at least two weekly doses with no AI. Give it some months to get through the transition. Only if your aromatization rate is high and you're having symptoms would I consider using the AI. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
High estradiol even on anastrazole
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