Hemochromatosis with CJC-1295 Ipamorelin Prescription

[Kyle Butler]

I was recently prescribed CJC-1295 and Ipamorelin + DHEA Pregnenolone scrotal cream. I have very low levels of IGF-1, pregnenolone, and DHEA. I am not on TRT.

I have hypothyroidism and I am on thyroid hormone replacement. I was recently diagnosed as a compound heterozygote for Hemochromatosis, meaning I have one C282Y mutation and one H63D mutation.

Can Iron Overload be causing my hypothyroidism and other low blood markers (also very high SHBG)? My iron labs indicate iron overload.

I read that in hemochromatosis, the body can store iron in the thyroid, pituitary, and adrenals. I am wondering if my thyroid, pituitary, and adrenals could be full of iron, and that is the reason they cannot produce adequate hormones.

The reason this is important is because I want to try phlebotomy before taking CJC-1295 and Ipamorelin if there’s a chance that I can regain my natural production of these hormones. Please advise.

Iron labs (all different labs/ranges)

2/2021
Iron: 133 (65-175)
TIBC: 239 L (261-462)
Transferrin % Saturation: 56 H (20-50)
Ferritin: 234 (18-464)
Folate: 12.6 (>2.8)

8/2021
Iron: 138 H (45-135)
TIBC: 217 L (250-400)
Transferrin % Saturation: 64 H (20-55)
Ferritin: 255 (20-335)
Folate: 12 (>=5)

4/2023
Iron: 138 (50-195)
TIBC: 25e L (250-425)
Transferrin: 178 L (188-341)
Transferrin % Saturation: 55 H (20-48)
Ferritin: 106 (38-380)
Ferritin is probably very low here because I had a lot of labs drawn about 3 weeks prior to this draw, so it was like a mini phlebotomy.

 

[DorianGray]

I do not believe iron overload is causing your hypothyroidism. I'm compound heterozygote (same variants as you) and have no hypothyroidism. You can google various medical sites that will tell you that combination does not typically result in organ damage due to iron metabolism. My total iron is 303, saturation 94, TIBC 324 (normal). My doctor did not seem concerned about those numbers, however I am, so I'm watching them carefully in future blood tests. Also, I've discontinued taking a Vit B12 supplement and Vit C both which can increase iron in genetically inclined people.
My advice to you is consult a doctor specializing in hematology. Primary care doctors do not get the big picture when it comes to this and/or don't give a damn.

 

[BigTex]

What is really eye opening about peptide sales is most of these online companies are also selling Semaglutide which is patented by Nova Nordisk and Tirzapatide which is patented by Eli Lilly. They are no longer selling just peptides, which is falls under the FDA, they are selling drugs which falls under the DEA. They are also violating patent rights. Yet no one has gotten busted.

 

[Kyle Butler]

I do not believe iron overload is causing your hypothyroidism. I'm compound heterozygote (same variants as you) and have no hypothyroidism. You can google various medical sites that will tell you that combination does not typically result in organ damage due to iron metabolism. My total iron is 303, saturation 94, TIBC 324 (normal). My doctor did not seem concerned about those numbers, however I am, so I'm watching them carefully in future blood tests. Also, I've discontinued taking a Vit B12 supplement and Vit C both which can increase iron in genetically inclined people.
My advice to you is consult a doctor specializing in hematology. Primary care doctors do not get the big picture when it comes to this and/or don't give a damn.

You have the same variant as me? That’s awesome. Not many people that are compound heterozygous. It is interesting to compare our numbers. They follow a similar pattern. If you don’t mind me asking, what age are you, how much red meat do you eat, and do you cook in a cast iron pan?

 

[DorianGray]

You have the same variant as me? That’s awesome. Not many people that are compound heterozygous. It is interesting to compare our numbers. They follow a similar pattern. If you don’t mind me asking, what age are you, how much red meat do you eat, and do you cook in a cast iron pan?

Age 72. It would be more negative impact to be H63D in both variants. Eat red meat very rarely, Mediterranean diet mostly for decades. Wife cooks in well-season cast iron pain maybe once a month. I have an appointment with a hematologist next month.

 

[Kyle Butler]

Age 72. It would be more negative impact to be H63D in both variants. Eat red meat very rarely, Mediterranean diet mostly for decades. Wife cooks in well-season cast iron pain maybe once a month. I have an appointment with a hematologist next month.

When you say homozygous H63D would be worse, do you mean because of H63D/Oslo Syndrome? Where NTBI (Non-Transferrin Bound Iron) accumulates in the brain without any cure including phlebotomy.

Also, interesting. Your lifestyle sounds good for someone with hemochromatosis. Pretty normal and moderate too. I personally have been eating a ton of red meat the past 3 years and cooking in a not-well-seasoned cast iron only for 1.5 years so that’s probably why I’ve been loading iron so badly. I hope your appointment goes well. Your Tsat is very high. I have read things on this forum about how low ferritin can be really bad, but I’m still skeptical. I don’t have a clear picture of what’s right and wrong yet but I want to find out how low ferritin can be while still being safe. I have a hematologist appointment coming up soon too.