I think you have such a effect with different doses because of Pregenenolone u-shape action Biphasic, U-shaped actions at the GABAa receptorHi all,
I've been experimenting with pregnenolone for over a year now, with varied success. I seem to get benefits at 100mg (such as higher libido, more pronounced nighttime erections and better sleep); however, I don't get these results consistently. If I try to continue 100mg daily, the effects start waning by the second day (my theory for this is possibly progesterone elevating too high). I've also tried lowering the dose to 10mg, 25mg and 50mg; however, oddly enough, I only seem to get the benefits at 100mg. Extended use at the other doses eventually builds up and produces only negative effects. Anyway, I was wondering if anybody could clarify the half-life of pregnenolone, its sulfate derivative, and its conversion to progesterone and could offer any insight on dosing frequency.
By the way, I've experimented with just progesterone, but the benefits are less pronounced, and I become more susceptible to the negative effects.
(sorry for the long-winded ramble)