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Hello, 57 year old about to start TRT and have questions
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<blockquote data-quote="tareload" data-source="post: 240046"><p>All great points you are bringing up that fall into three general sections:</p><p></p><ol> <li data-xf-list-type="ol">Area Under Curve (AUC) for endogenous production vs TRT (exogeneous T administration) and mg/day T produced by body vs mg/day injected (AUC for both should be same over a week if the mean daily exo T admin or endo production are the same)</li> <li data-xf-list-type="ol">Here's where things getting confusing for dudes: AUC for XXX ng/dl <strong>peak</strong> TT/fT (natural guy) vs same ng/dl TT/fT for TRT guys (is it measured peak/trough?)</li> <li data-xf-list-type="ol">Effect of exogenous T administration on HPTA feedback (pulse frequency and amplitude) and what that means for the rest of your hormones besides T and E.</li> </ol><p></p><p></p><p>This thread does a decent job explaining key concepts for 1 and 2 (see these posts in particular):</p><p>[URL unfurl="true"]https://forums.t-nation.com/t/natural-levels-vs-trt-levels/279493/2[/URL]</p><p>[URL unfurl="true"]https://forums.t-nation.com/t/natural-levels-vs-trt-levels/279493/27[/URL]</p><p></p><p></p><p>Item 3 is touched on here and see second thread for details:</p><p>[URL unfurl="true"]https://forums.t-nation.com/t/help-advice-interpreting-my-labs-fertility-after-blast-cruise/268309/45[/URL]</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/chapter-12-hypothalamo-pituitary-unit-testis-and-male-accessory-organs.24827/[/URL]</p><p></p><p><img src="https://www.excelmale.com/forum/attachments/1644521976015-png.19672/" class="bbImage" alt="" data-url="https://www.excelmale.com/forum/attachments/1644521976015-png.19672/" style="" /></p><p></p><p></p><p>Pulse frequency and amplitude of the exogenous Test dose matter with respect to negative feedback to the HPTA.</p><p></p><p>Note: I have left T-Nation but spent so much time typing over there that I often link to stuff there (which is many times stolen from the geniuses over here [USER=13851]@madman[/USER] [USER=38109]@Cataceous[/USER], etc). So I appreciate the Mods allowing me to post these links even though typically this would be frowned upon. There is so much information if you search the threads here!</p><p></p><p>Check out this embarrassment of riches by [USER=42264]@Fortunate[/USER] ...</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/official-natesto-thread.23541/[/URL]</p></blockquote><p></p>
[QUOTE="tareload, post: 240046"] All great points you are bringing up that fall into three general sections: [LIST=1] [*]Area Under Curve (AUC) for endogenous production vs TRT (exogeneous T administration) and mg/day T produced by body vs mg/day injected (AUC for both should be same over a week if the mean daily exo T admin or endo production are the same) [*]Here's where things getting confusing for dudes: AUC for XXX ng/dl [B]peak[/B] TT/fT (natural guy) vs same ng/dl TT/fT for TRT guys (is it measured peak/trough?) [*]Effect of exogenous T administration on HPTA feedback (pulse frequency and amplitude) and what that means for the rest of your hormones besides T and E. [/LIST] This thread does a decent job explaining key concepts for 1 and 2 (see these posts in particular): [URL unfurl="true"]https://forums.t-nation.com/t/natural-levels-vs-trt-levels/279493/2[/URL] [URL unfurl="true"]https://forums.t-nation.com/t/natural-levels-vs-trt-levels/279493/27[/URL] Item 3 is touched on here and see second thread for details: [URL unfurl="true"]https://forums.t-nation.com/t/help-advice-interpreting-my-labs-fertility-after-blast-cruise/268309/45[/URL] [URL unfurl="true"]https://www.excelmale.com/forum/threads/chapter-12-hypothalamo-pituitary-unit-testis-and-male-accessory-organs.24827/[/URL] [IMG]https://www.excelmale.com/forum/attachments/1644521976015-png.19672/[/IMG] Pulse frequency and amplitude of the exogenous Test dose matter with respect to negative feedback to the HPTA. Note: I have left T-Nation but spent so much time typing over there that I often link to stuff there (which is many times stolen from the geniuses over here [USER=13851]@madman[/USER] [USER=38109]@Cataceous[/USER], etc). So I appreciate the Mods allowing me to post these links even though typically this would be frowned upon. There is so much information if you search the threads here! Check out this embarrassment of riches by [USER=42264]@Fortunate[/USER] ... [URL unfurl="true"]https://www.excelmale.com/forum/threads/official-natesto-thread.23541/[/URL] [/QUOTE]
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Hello, 57 year old about to start TRT and have questions
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