ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Has Anyone Stopped HCG
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 215618" data-attributes="member: 38109"><p>This is the study that shows an apparent half-life of ten days (239.63 hours). They don't say how it was calculated. It seems a little long compared to what can be derived from the average Cmax and Cmin values.</p><p></p><p>In any case, regarding accumulation, I think the confounding factor is that the men had functional HPTAs at the start. This means that their own production was declining in the early weeks of the study. The buildup in the 50 mg cohort is better masked by their declining natural production. If you wanted to clearly see the accumulation then you'd need to remove endogenous testosterone from the subjects with a GnRH agonist prior to the study. The peaks will always appear to rise with the first few doses unless the half-life is relatively small compared to the dosing interval. For example, even a 3.5 day half-life leaves a residual of one quarter of the previous dose to be added to the next dose, with weekly dosing. But the residual of 1/16 the dose from two weeks back is already becoming a pretty small contribution.</p><p></p><p>I've been saying that with regard to serum variation, taking Xyosted weekly is similar to taking regular cypionate or enanthate twice weekly. This relies on the Xyosted calculation of apparent half-life. If this calculation is on the high side then the equivalent interval for the other products would be longer.</p><p></p><p>The "therapeutic window" you refer to can be adjusted arbitrarily by changing the injection interval relative to the half-life of the ester. Even with a short-acting ester such as testosterone propionate you can reduce the window to virtually nothing if you were willing to inject tiny amounts every few minutes. Xyosted lacks the flexibility of other products because of the three fixed doses. You can still go off-label and inject more or less frequently than weekly.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 215618, member: 38109"] This is the study that shows an apparent half-life of ten days (239.63 hours). They don't say how it was calculated. It seems a little long compared to what can be derived from the average Cmax and Cmin values. In any case, regarding accumulation, I think the confounding factor is that the men had functional HPTAs at the start. This means that their own production was declining in the early weeks of the study. The buildup in the 50 mg cohort is better masked by their declining natural production. If you wanted to clearly see the accumulation then you'd need to remove endogenous testosterone from the subjects with a GnRH agonist prior to the study. The peaks will always appear to rise with the first few doses unless the half-life is relatively small compared to the dosing interval. For example, even a 3.5 day half-life leaves a residual of one quarter of the previous dose to be added to the next dose, with weekly dosing. But the residual of 1/16 the dose from two weeks back is already becoming a pretty small contribution. I've been saying that with regard to serum variation, taking Xyosted weekly is similar to taking regular cypionate or enanthate twice weekly. This relies on the Xyosted calculation of apparent half-life. If this calculation is on the high side then the equivalent interval for the other products would be longer. The "therapeutic window" you refer to can be adjusted arbitrarily by changing the injection interval relative to the half-life of the ester. Even with a short-acting ester such as testosterone propionate you can reduce the window to virtually nothing if you were willing to inject tiny amounts every few minutes. Xyosted lacks the flexibility of other products because of the three fixed doses. You can still go off-label and inject more or less frequently than weekly. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Has Anyone Stopped HCG
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top