Systemlord
Member
The biologic role of estrone in men has remained unappreciated. Although estrone is a weaker estrogen than estradiol in some bioassays, circulating estrone levels in men are higher than those of estradiol. Estrone can also be converted in the body to estradiol.
www.ncbi.nlm.nih.gov
Estrone can also be reversibly converted into estradiol by 17β-HSD
Circulating Estrone Levels Are Associated Prospectively With Diabetes Risk in Men of the Framingham Heart Study
In postmenopausal women and preclinical murine models, estrogen administration reduces diabetes risk; however, the relationship of estradiol and estrone to diabetes in men is poorly understood. We determined the relationship between circulating estradiol ...
www.ncbi.nlm.nih.gov
Estrone can also be reversibly converted into estradiol by 17β-HSD
No, that would be estriol. "... estradiol is about 10-fold more potent than estrone and about 100-fold more potent than estriol."[R]
I checked it once out of curiosity. It was during a period when my estradiol was undetectable. Interestingly, estrone was normal, 55 pg/mL (15-65).
Okay so home come fella has perfect bloodwork minus his estrone, it is whack and luckily his doctor tested his estrone and now they think that's why he has high estrogen symptoms.
It's two folds above the range. But estradiol is 27, tt and ft higher in the range.
Went from IM to SubQ
It's two folds above the range. But estradiol is 27, tt and ft higher in the range.
Went from IM to SubQ
Guitarman5
New Member
My naturopath checked my Estrone because I always run high on DHEA-S (742ug/dL 138.5-475.2 last time I checked) and my Estrone came out to 111pg/mL (15-65). I would definitely get your DHEA checked especially if your E2 is normal.
Dhea always high
Go back to your facebook group or whatever other cult you crawled out from.
Read well and comment afterwards.
"In postmenopausal women as in men, [estradiol](https://www.sciencedirect.com/topics/medicine-and-dentistry/estradiol) no longer functions as a circulating hormone, because it ceases to be formed by the [ovaries](https://www.sciencedirect.com/topics/medicine-and-dentistry/ovary) at the time of menopause. Estradiol continues to be formed in a number of extragonadal sites, however, including breast, bone, [vascular smooth muscle](https://www.sciencedirect.com/topics/medicine-and-dentistry/vascular-smooth-muscle), and various sites in the brain. At these sites of formation, local estradiol levels can be quite high, but the production rate is insufficient to affect the body in a global fashion; thus, [estrogen action](https://www.sciencedirect.com/topics/medicine-and-dentistry/estrogen-activity) at these extragonadal sites of synthesis is primarily at a local level and serves a paracrine or even intracrine role.
Because of this, in postmenopausal women as in men, circulating estrogen levels do not drive growth and development of target tissues. Instead, they reflect the metabolism of estradiol at these extragonadal sites. Estrogen that is not metabolized at these sites reenters the circulation, and, consequently, circulating levels of estradiol reflect its synthesis and action in extragonadal sites. Thus, they are reactive instead of proactive. An important difference between [estrogen production](https://www.sciencedirect.com/topics/medicine-and-dentistry/estrogen-synthesis) at these extragonadal sites and estrogen that is synthesized in the ovary is that the former is absolutely dependent on a supply of circulating C19 androgenic substrate.
Conclusion(s): Circulating levels of [testosterone](https://www.sciencedirect.com/topics/medicine-and-dentistry/testosterone) begin to decline in the mid-reproductive years, and the levels of adrenal androgenic steroids, namely adrostenedione and [DHEA](https://www.sciencedirect.com/topics/medicine-and-dentistry/prasterone), decrease throughout postmenopausal life. Therefore, the circulating levels of these adrogenic steroids may serve an important role in the maintenance of local estrogen synthesis, for example, in the bone and brain where estrogen has a profound influence on the maintenance of [mineralization](https://www.sciencedirect.com/topics/medicine-and-dentistry/mineralization) on the one hand, and possible cognitive function on the other."
[https://www.sciencedirect.com/scien...ct.com/science/article/pii/S0015028202029849)
This is overstated, and on this point your reference should not be lumping men in with menopausal women. Men continue to rely on the gonads as the primary source of testosterone, a process that is regulated somewhat by serum testosterone, but primarily by serum levels of one of its metabolites: estradiol. A significant fraction of men's estradiol is produced intratesticularly, driven by levels of testosterone and luteinizing hormone. In essence the body is regulating testosterone production to achieve its preferred serum level of estradiol. This belies the idea that serum levels don't matter.
If you think serum levels are unimportant then trying injecting 20 mg of estradiol cypionate a week to see what happens. It shouldn't interfere too much with the intracrine processes, but you might discover some of estradiol's endocrine properties.
DixieWrecked
Well-Known Member
Can we go ahead and ban Danny, I mean Eagleface?
I had a good laugh! Thanks
Estrogen would be the weakest. E1 and E2 are bidirectional. E2 would be considered the most potent.
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