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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
First Lab Post! “Should I stay or should I go?”...would appreciate some guidance. Thank you!
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<blockquote data-quote="Cataceous" data-source="post: 221518" data-attributes="member: 38109"><p>If you can get it, enclomiphene is preferred over Clomid/clomiphene. Clomid is just enclomiphene and zuclomiphene. The latter is estrogenic and usually unhelpful. Resuming SERM monotherapy is a reasonable option, especially since you did well with Clomid. I would not use hCG with Natesto or a SERM because it can be suppressive and work against the HPTA function you're trying to maintain or stimulate. Natesto with a SERM is potentially viable and maybe even beneficial. Natesto still suppresses the HPTA a little and a SERM would tend to counteract that.</p><p></p><p>I believe that adding a SERM such as enclomiphene to conventional TRT will most often fail to significantly stimulate the HPTA. The matter has not been decided definitively, as there are anecdotes going both ways. It's true that estrogens form the most potent mechanism of negative feedback in the HPTA, and SERMs can block this feedback. However, androgens also provide negative feedback at the hypothalamus, and SERMs do not affect this. I use enclomiphene with TRT, but this is in conjunction with gonadorelin (GnRH), which effectively bypasses the hypothalamus and directly stimulates the pituitary to make LH. I also see a drop in IGF-1 with enclomiphene use, though not as dramatic as yours. In a way it's beneficial to me because it allows me to use ipamorelin as a sleep aid with less worry about elevating IGF-1.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 221518, member: 38109"] If you can get it, enclomiphene is preferred over Clomid/clomiphene. Clomid is just enclomiphene and zuclomiphene. The latter is estrogenic and usually unhelpful. Resuming SERM monotherapy is a reasonable option, especially since you did well with Clomid. I would not use hCG with Natesto or a SERM because it can be suppressive and work against the HPTA function you're trying to maintain or stimulate. Natesto with a SERM is potentially viable and maybe even beneficial. Natesto still suppresses the HPTA a little and a SERM would tend to counteract that. I believe that adding a SERM such as enclomiphene to conventional TRT will most often fail to significantly stimulate the HPTA. The matter has not been decided definitively, as there are anecdotes going both ways. It's true that estrogens form the most potent mechanism of negative feedback in the HPTA, and SERMs can block this feedback. However, androgens also provide negative feedback at the hypothalamus, and SERMs do not affect this. I use enclomiphene with TRT, but this is in conjunction with gonadorelin (GnRH), which effectively bypasses the hypothalamus and directly stimulates the pituitary to make LH. I also see a drop in IGF-1 with enclomiphene use, though not as dramatic as yours. In a way it's beneficial to me because it allows me to use ipamorelin as a sleep aid with less worry about elevating IGF-1. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
First Lab Post! “Should I stay or should I go?”...would appreciate some guidance. Thank you!
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