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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Finasteride for hair loss
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<blockquote data-quote="madman" data-source="post: 205500" data-attributes="member: 13851"><p><em><strong>12.2 Post finasteride syndrome (PFS)</strong></em></p><p><em></em></p><p><em>Several groups around the world have coined the term “Post finasteride syndrome (PFS)” in a subset of men who used finasteride, who experienced<strong> persistent sexual dysfunction (decreased libido and ejaculation disorder) and psychological effects (increased depression, anxiety, and suicidal ideas) after cessation of therapy, irrespective of age, drug, or duration of treatment (81,83). </strong>Men using finasteride for more than 205 days had a higher risk for persistent erectile dysfunction (76,84).</em></p><p><em></em></p><p><em>The association of sexual and nonsexual side effects in former finasteride users may be due to the fact that</em><strong><em> <u>finasteride irreversibly inhibits 5AR with a slow rate of dissociation</u>, probably leading to a long-lasting effect on the body, regardless of the time and dose of administration (83).<u> Additionally, an alteration in the brain neurosteroids such as progesterone and dihydroprogesterone </u>could possibly contribute to the persistent psychological effects, as the inhibition of 5AR is a rate-limiting step in the production of neurosteroids (76,85). </em></strong><em>Preclinical animal studies showed that finasteride lowered plasma and hippocampal neurosteroids and increased depression (86,87).</em></p></blockquote><p></p>
[QUOTE="madman, post: 205500, member: 13851"] [I][B]12.2 Post finasteride syndrome (PFS)[/B] Several groups around the world have coined the term “Post finasteride syndrome (PFS)” in a subset of men who used finasteride, who experienced[B] persistent sexual dysfunction (decreased libido and ejaculation disorder) and psychological effects (increased depression, anxiety, and suicidal ideas) after cessation of therapy, irrespective of age, drug, or duration of treatment (81,83). [/B]Men using finasteride for more than 205 days had a higher risk for persistent erectile dysfunction (76,84). The association of sexual and nonsexual side effects in former finasteride users may be due to the fact that[/I][B][I] [U]finasteride irreversibly inhibits 5AR with a slow rate of dissociation[/U], probably leading to a long-lasting effect on the body, regardless of the time and dose of administration (83).[U] Additionally, an alteration in the brain neurosteroids such as progesterone and dihydroprogesterone [/U]could possibly contribute to the persistent psychological effects, as the inhibition of 5AR is a rate-limiting step in the production of neurosteroids (76,85). [/I][/B][I]Preclinical animal studies showed that finasteride lowered plasma and hippocampal neurosteroids and increased depression (86,87).[/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Finasteride for hair loss
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