Appassionato
Active Member
I was looking for something else, when I came across this study:
Estradiol stimulates cortisol production by adrenal cells in estrogen-dependent primary adrenocortical nodular dysplasia. - PubMed - NCBI
It's an old study and it has been performed on a single patient with ACTH-independent Cushing's syndrome, but it gave me a hint of what I've always suspected, which is E2 induced hypercortisolemia.
So, thinking out loud, the outcome would be excess T aromatized into E2, which in excess stimulates the adrenals to produce more cortisol and the pituitary gland to produce more prolactin, as shown by this study:
Testosterone-induced hyperprolactinaemia in a patient with a disturbance of hypothalamo-pituitary regulation. - PubMed - NCBI
That would suit perfectly my blood test values and probably would explain why many people experience exacerbated anxiety while on TRT.
Obviously this is just an exemplification and it could be that I'm missing something here, but I wanted to share my thoughts.
Estradiol stimulates cortisol production by adrenal cells in estrogen-dependent primary adrenocortical nodular dysplasia. - PubMed - NCBI
It's an old study and it has been performed on a single patient with ACTH-independent Cushing's syndrome, but it gave me a hint of what I've always suspected, which is E2 induced hypercortisolemia.
So, thinking out loud, the outcome would be excess T aromatized into E2, which in excess stimulates the adrenals to produce more cortisol and the pituitary gland to produce more prolactin, as shown by this study:
Testosterone-induced hyperprolactinaemia in a patient with a disturbance of hypothalamo-pituitary regulation. - PubMed - NCBI
That would suit perfectly my blood test values and probably would explain why many people experience exacerbated anxiety while on TRT.
Obviously this is just an exemplification and it could be that I'm missing something here, but I wanted to share my thoughts.
