Elevated IGF-1 levels
- Thread starter pyater
- Start date
what were they before you started?
Dr Justin Saya MD
Moderator
So started TRT with Test Cyp shots monthly in August 2018. No pre-TRT IGF-1 measurement at that point. Switched Dr.'s and protocols in February 2019.
Last Test Cyp shot was 12/19/18 (400 mg - every three weeks was protocol at that point). First IGF-1 measurement was 1/25/19 at 218 prior to switching.
Started new T cream protocol on 2/26/19 subsequent IGF-1 labs:
4/20/19 - 274
4/30/19 - 336
T levels and Estradiol - Sensitive were high with same lab work and protocol has been adjusted.
Total T - >1500
Free T - 41.5
Estradiol - Sensitive - 64.2
Last Test Cyp shot was 12/19/18 (400 mg - every three weeks was protocol at that point). First IGF-1 measurement was 1/25/19 at 218 prior to switching.
Started new T cream protocol on 2/26/19 subsequent IGF-1 labs:
4/20/19 - 274
4/30/19 - 336
T levels and Estradiol - Sensitive were high with same lab work and protocol has been adjusted.
Total T - >1500
Free T - 41.5
Estradiol - Sensitive - 64.2
Anyone else experiencing elevated IGF-1 levels? My bounces around a bit. Endo just ordered a follow-up panel. Still seeing elevated levels from this prior post and have changes protocols see below.
Last reading (October) was:
IGF-1 - 324 ng/ml = Reference range for my age (81 - 263 ng/mL)
Total T - 503 –
Free T - 22.6 - Ref Range (6.8-21.5)
Ha1C - 5.5
Prior panel (July 2020) = Endo doesn't do a full panel and I am a few months from my Defy follow-up
IGF-1 - 269 ng/ml = Reference range for my age (81 - 263 ng/mL)
Total T - 636 –
Free T - 16 - Ref Range (6.8-21.5)
SHGB - 28.4
DHT-32
DHEA - 270
E2 - 33.1
Current Protocol - Since May - Switched from compounded cream
.35ml Test Cyp 200 mg/ml twice per week, no AI, no HCG, I do take DIM and CDC.
Thoughts, anyone else see this? I read all of the bad stuff about elevated IGF-1 and risks. I did have a pituitary MRI back in May of 2018 and it was clear. Have done a Glucose Tolerance test for GH and it was normal. There are some studies out there that show TRT increases IGF-1.
www.ncbi.nlm.nih.gov
Last reading (October) was:
IGF-1 - 324 ng/ml = Reference range for my age (81 - 263 ng/mL)
Total T - 503 –
Free T - 22.6 - Ref Range (6.8-21.5)
Ha1C - 5.5
Prior panel (July 2020) = Endo doesn't do a full panel and I am a few months from my Defy follow-up
IGF-1 - 269 ng/ml = Reference range for my age (81 - 263 ng/mL)
Total T - 636 –
Free T - 16 - Ref Range (6.8-21.5)
SHGB - 28.4
DHT-32
DHEA - 270
E2 - 33.1
Current Protocol - Since May - Switched from compounded cream
.35ml Test Cyp 200 mg/ml twice per week, no AI, no HCG, I do take DIM and CDC.
Thoughts, anyone else see this? I read all of the bad stuff about elevated IGF-1 and risks. I did have a pituitary MRI back in May of 2018 and it was clear. Have done a Glucose Tolerance test for GH and it was normal. There are some studies out there that show TRT increases IGF-1.
Effects of transdermal testosterone gel or an aromatase inhibitor on serum concentration and pulsatility of growth hormone in older men with age-related low testosterone
Growth hormone is the major regulator of growth and body composition. Pulsatile GH secretion declines exponentially with age. Testosterone replacement is being increasingly offered to older men with age-related low testosterone. Testosterone administration ...
www.ncbi.nlm.nih.gov
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