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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
edema[swelling] what is the cause
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<blockquote data-quote="Nelson Vergel" data-source="post: 19893" data-attributes="member: 3"><p>"There is an enzyme that is localized primarily in the kidneys whose function is to protect the kidneys from circulating cortisol. The kidneys have receptors called mineralcorticoid receptors (MR's) which are meant to bind to specific adrenal hormones (called mineralcorticoids) in the body such as aldosterone. The result of this binding is a signal to increase sodium and water retention in the body, while stimulating the excretion of potassium. This is an important mechanism to maintain fluid and electrolyte balance in the body.A problem exists though in that cortisol can also bind activate these receptors. Cortisol is a widely circulating hormone and serves a multitude of functions throughout the body. However its intended biological functions do not include mineralcorticoid action in the kidneys, so to prevent this from happening the kidneys are rich in the enzyme 11b-hydroxysteroid dehydrogenase 2 (11b-HSD2). This enzyme deactivates cortisol by converting it into cortisone before it can bind to the renal MRs.</p><p>Certain substances can block 11b-HSD2, and that can lead to problems." Testosterone is one of them.</p><p></p><p><a href="http://patrickarnoldblog.com/hypertension-and-anabolic-steroids-a-new-pathway/" target="_blank">http://patrickarnoldblog.com/hypertension-and-anabolic-steroids-a-new-pathway/</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 19893, member: 3"] "There is an enzyme that is localized primarily in the kidneys whose function is to protect the kidneys from circulating cortisol. The kidneys have receptors called mineralcorticoid receptors (MR's) which are meant to bind to specific adrenal hormones (called mineralcorticoids) in the body such as aldosterone. The result of this binding is a signal to increase sodium and water retention in the body, while stimulating the excretion of potassium. This is an important mechanism to maintain fluid and electrolyte balance in the body.A problem exists though in that cortisol can also bind activate these receptors. Cortisol is a widely circulating hormone and serves a multitude of functions throughout the body. However its intended biological functions do not include mineralcorticoid action in the kidneys, so to prevent this from happening the kidneys are rich in the enzyme 11b-hydroxysteroid dehydrogenase 2 (11b-HSD2). This enzyme deactivates cortisol by converting it into cortisone before it can bind to the renal MRs. Certain substances can block 11b-HSD2, and that can lead to problems." Testosterone is one of them. [URL]http://patrickarnoldblog.com/hypertension-and-anabolic-steroids-a-new-pathway/[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
edema[swelling] what is the cause
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