E2 Sweetspot - Larger Erection Than Normal?

[Robotics]

Yesterday i took my AI and Cialis 2 hours before sexual activity and had an erection that i would describe as larger than normal. I have done so before (take cialis daily and ai eod) but have not had the same results. The next day i took cialis and did not have the same large erection

Is this a sign my e2 is too high in general perhaps? at 2 hours anastrozole is at max concentration, by the next day the concentration would be lower?

 

[Cataceous]

Even though the serum concentration of anastrozole might peak in a couple hours, the effects on estradiol should be further delayed. Anastrozole is reducing the formation of new estradiol, but does not affect existing estradiol. If the half-life of estradiol is short enough then it's conceivable that you could see a drop in that time frame, but I wonder if it could really be significant enough to influence sexual function.

 

[Robotics]

did anyone find that their e2 level correlated with a fuller/larger than normal erection?

 

[Vince]

did anyone find that their e2 level correlated with a fuller/larger than normal erection?

It all honesty, I’ve never felt anything from E2 levels.

 

[Robotics]

It all honesty, I’ve never felt anything from E2 levels.

you are high shbg right? less free e2 fluctuation i am guessing. I am a low shbg guy.

 

[Tman]

I am not sure what caused it, but about 8 months ago, I had a larger than ever erection...we both noticed it. I was in hcg at the time, but I had to stop due to side effects. If I can ever feel dialed in on trt, I want to try hcg again for the fourth time. I cant seem to make it past the first week before anxiety kicks in.

 

[Vince]

you are high shbg right? less free e2 fluctuation i am guessing. I am a low shbg guy.

My last labs

Testosterone, Serum 1118 Reference Range: 264-916 ng/dL
Free Testosterone(Direct) 27.3 Reference Range: 6.6-18.1 pg/mL
Estradiol, Sensitive 19.8 Reference Range: 8.0-35.0 of/mL
SHBG 47.7 Reference Range: 19.3-76.4 nmol/L
DHEA-Sulfate 424.8 Reference Range: 30.9-295.6 ug/dL (age adjusted)
Albumin 4.3 Reference Range: 3.6-4.8 g/dL
Tru T 38.46 range 16-31 ng/dL

 

[DS3]

did anyone find that their e2 level correlated with a fuller/larger than normal erection?

As my estrogen approach ~60-70 pg/mL, my erections are as full as possible. When I knock estrogen down to 30-40 pg/mL, my erections are much softer and it is much harder to orgasm. Estrogen plays a critical role in erectile function.

 

[Gman86]

As my estrogen approach ~60-70 pg/mL, my erections are as full as possible. When I knock estrogen down to 30-40 pg/mL, my erections are much softer and it is much harder to orgasm. Estrogen plays a critical role in erectile function.

Where does ur SHBG sit?

 

[DS3]

Where does ur SHBG sit?

~20 nmol/L

 

[Gman86]

~20 nmol/L

Surprised u feel better with those higher E2 levels, considering where ur SHBG is, but just goes to show how different we all are

 

[Nixter]

My last labs

Testosterone, Serum 1118 Reference Range: 264-916 ng/dL
Free Testosterone(Direct) 27.3 Reference Range: 6.6-18.1 pg/mL
Estradiol, Sensitive 19.8 Reference Range: 8.0-35.0 of/mL
SHBG 47.7 Reference Range: 19.3-76.4 nmol/L
DHEA-Sulfate 424.8 Reference Range: 30.9-295.6 ug/dL (age adjusted)
Albumin 4.3 Reference Range: 3.6-4.8 g/dL
Tru T 38.46 range 16-31 ng/dL

Nice labs! What's your protocol? Do you require a fairly high TRT dosage to achieve those T numbers, given your relatively high SHBG?

 

[Vince]

Nice labs! What's your protocol? Do you require a fairly high TRT dosage to achieve those T numbers, given your relatively high SHBG?

16 mg of testosterone cypionate daily, 500 iu of hcg twice a week and no AI.

 

[DS3]

Surprised u feel better with those higher E2 levels, considering where ur SHBG is, but just goes to show how different we all are

I think the biggest factor is that I react very poorly (subjectively speaking) to AIs, so I avoid it as much as possible. But I do feel better with higher estrogen as opposed to lower.

 

[Nixter]

16 mg of testosterone cypionate daily, 500 iu of hcg twice a week and no AI.

Interesting! 112mg/wk, I'm surprised your free T is so high with that SHBG. Although I guess you don't really have a trough at which to do blood work. And why daily with an SHBG like yours? Just to keep everything as stable as possible?

 

[Gman86]

I think the biggest factor is that I react very poorly (subjectively speaking) to AIs, so I avoid it as much as possible. But I do feel better with higher estrogen as opposed to lower.

Same. I never felt ideal on ai’s. Libido and erections were also hit or miss. Without an ai libido and erections are very consistent. Whether both are great or sub-par, they’ve always been consistent at that time without ai’s. I also seem to feel better E2 on the higher end, but my SHBG is usually high 30’s to low 40’s, and binds like crazy. I swear it binds like my SHBG is 50-60. So makes sense why I would feel better with a bit higher E2. A little surprised u feel so good with higher E2 with a SHBG of 20, but really just proves that everyone is unique and everyone needs to find what works for them as individuals

 

[DS3]

Same. I never felt ideal on ai’s. Libido and erections were also hit or miss. Without an ai libido and erections are very consistent. Whether both are great or sub-par, they’ve always been consistent at that time without ai’s. I also seem to feel better E2 on the higher end, but my SHBG is usually high 30’s to low 40’s, and binds like crazy. I swear it binds like my SHBG is 50-60. So makes sense why I would feel better with a bit higher E2. A little surprised u feel so good with higher E2 with a SHBG of 20, but really just proves that everyone is unique and everyone needs to find what works for them as individuals

If there were a way to increase SHBG I would.

 

[Gman86]

If there were a way to increase SHBG I would.

Haven’t seen a way either. Obv everyone says to improve insulin sensitivity, but I’ve never seen that work in real life. Although not sure if I’ve ever seen anyone try. Either way I’ll believe that theory when I see it

 

[DS3]

Haven’t seen a way either. Obv everyone says to improve insulin sensitivity, but I’ve never seen that work in real life. Although not sure if I’ve ever seen anyone try. Either way I’ll believe that theory when I see it

I think that’s based on the factor that those with insulin resistance (outside of TRT) have low SHBG (probably as a result of lowered TT so the SHBG is decreased to maintain free T). Anabolic steroids including T decrease SHBG without any changes in blood glucose (including A1C) from my current knowledge. So I believe that inproving insulin sensitivity would be effective in those with insulin resistance, but perhaps not for those who are not insulin resistant.

What are your thoughts?

 

[Gman86]

I think that’s based on the factor that those with insulin resistance (outside of TRT) have low SHBG (probably as a result of lowered TT so the SHBG is decreased to maintain free T). Anabolic steroids including T decrease SHBG without any changes in blood glucose (including A1C) from my current knowledge. So I believe that inproving insulin sensitivity would be effective in those with insulin resistance, but perhaps not for those who are not insulin resistant.

What are your thoughts?

Not sure honestly. Haven’t really seen many people experiment and try to raise low SHBG by improving their insulin sensitivity. Do u know where u sit insulin resistance wise?

What’s the best way to test for insulin resistance? Just test fasting insulin levels? Or do u look at insulin levels, A1C and fasting glucose levels, and make an assessment based on all 3?