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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Does testosterone replacement cause primary hypogonadism?
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<blockquote data-quote="Jeffrey Becker" data-source="post: 3750" data-attributes="member: 266"><p>Gene is correct the cause of the steroid induced hypogonadism is lack of LH signaling due to pituitary shutdown (secondary hypogonadism). </p><p></p><p>My thinking, was along the lines that, the longer the cycle of TRT, the testes atrophy or shutdown due to this lack of signaling - at least until signaling to the testes is resumed, and they have a chance to recover. Recovery is not typically immediate depending how long and severe the shutdown. So there can be a degree of primary dysfunction or impairment which results. Function is typically recovered gradually when TRT ends or HCG is utilized. By definition this is considered secondary. However, if the testes were not able to recover, it would be primary at that point (similar to castration).</p><p></p><p>Sorry if I confused this issue.</p></blockquote><p></p>
[QUOTE="Jeffrey Becker, post: 3750, member: 266"] Gene is correct the cause of the steroid induced hypogonadism is lack of LH signaling due to pituitary shutdown (secondary hypogonadism). My thinking, was along the lines that, the longer the cycle of TRT, the testes atrophy or shutdown due to this lack of signaling - at least until signaling to the testes is resumed, and they have a chance to recover. Recovery is not typically immediate depending how long and severe the shutdown. So there can be a degree of primary dysfunction or impairment which results. Function is typically recovered gradually when TRT ends or HCG is utilized. By definition this is considered secondary. However, if the testes were not able to recover, it would be primary at that point (similar to castration). Sorry if I confused this issue. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Does testosterone replacement cause primary hypogonadism?
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