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Different Types of Iron Deficiency
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<blockquote data-quote="madman" data-source="post: 208500" data-attributes="member: 13851"><p><strong>Panel 2: Future research and clinical directions </strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Epidemiology</strong></p><p><strong></strong></p><p><strong><em>• Improved data on the prevalence of iron deficiency across low-income, middle-income, and high-income countries through routine incorporation of iron biomarkers in population surveys will enable appropriate targeting of public health and clinical interventions </em></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Diagnosis </strong></p><p><strong></strong></p><p><strong><em>• Rational, evidence-based thresholds for defining iron deficiency using existing biomarkers, such as ferritin and standardised soluble transferrin receptor, and available but underused biomarkers, such as reticulocyte haemoglobin content </em></strong></p><p><strong><em></em></strong></p><p><strong><em>• Identification and validation of functional markers of iron deficiency beyond haemoglobin </em></strong></p><p><strong><em></em></strong></p><p><strong><em>• Introduction of standardised hepcidin measurement into routine clinical diagnosis through availability on automated laboratory platforms </em></strong></p><p></p><p><em><strong>• Non-invasive faecal and blood-based tools and improved imaging technology to detect luminal pathologies, such as malignancy and coeliac disease</strong></em></p><p></p><p></p><p><strong>Treatment</strong></p><p><strong></strong></p><p><strong><em>• Further characterisation of the clinical role and safety of parenteral iron across the range of iron deficiency syndromes, clinical disease groups, and demographic populations </em></strong></p><p></p><p><em><strong>• Development of personalised iron supplementation strategies based on genetic loci that are associated with treatment outcomes of iron supplementation </strong></em></p><p><em><strong></strong></em></p><p><em><strong>• Clarification of clinical implications and role for screening and treatment of parenteral iron-induced hypophosphataemia </strong></em></p><p><em><strong></strong></em></p><p><em><strong>• Characterisation of possible long-term adverse effects of sustained parenteral iron therapy in patients with functional iron deficiency (including chronic kidney disease) </strong></em></p><p><em><strong></strong></em></p><p><em><strong>• Introduction of novel therapies for functional iron deficiency that inhibits hepcidin production, directly target hepcidin itself, or prevent its action on ferroportin; or promote erythropoietin production and iron transport </strong></em></p><p></p><p><strong><em>• Improved understanding of the benefits, risks, and optimal approaches for delivering iron to prevent and treat anaemia in children, adolescents, and women in low-income countries</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 208500, member: 13851"] [B]Panel 2: Future research and clinical directions Epidemiology [I]• Improved data on the prevalence of iron deficiency across low-income, middle-income, and high-income countries through routine incorporation of iron biomarkers in population surveys will enable appropriate targeting of public health and clinical interventions [/I] Diagnosis [I]• Rational, evidence-based thresholds for defining iron deficiency using existing biomarkers, such as ferritin and standardised soluble transferrin receptor, and available but underused biomarkers, such as reticulocyte haemoglobin content • Identification and validation of functional markers of iron deficiency beyond haemoglobin • Introduction of standardised hepcidin measurement into routine clinical diagnosis through availability on automated laboratory platforms [/I][/B] [I][B]• Non-invasive faecal and blood-based tools and improved imaging technology to detect luminal pathologies, such as malignancy and coeliac disease[/B][/I] [B]Treatment [I]• Further characterisation of the clinical role and safety of parenteral iron across the range of iron deficiency syndromes, clinical disease groups, and demographic populations [/I][/B] [I][B]• Development of personalised iron supplementation strategies based on genetic loci that are associated with treatment outcomes of iron supplementation • Clarification of clinical implications and role for screening and treatment of parenteral iron-induced hypophosphataemia • Characterisation of possible long-term adverse effects of sustained parenteral iron therapy in patients with functional iron deficiency (including chronic kidney disease) • Introduction of novel therapies for functional iron deficiency that inhibits hepcidin production, directly target hepcidin itself, or prevent its action on ferroportin; or promote erythropoietin production and iron transport [/B][/I] [B][I]• Improved understanding of the benefits, risks, and optimal approaches for delivering iron to prevent and treat anaemia in children, adolescents, and women in low-income countries[/I][/B] [/QUOTE]
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